Method of Diagnosis of Chronic Kidney Disease with Pharmacogenomics Support

A method for determining a subject's risk for developing chronic kidney disease (CKD) combined with determining a subject's pharmacogenomic (PGX) profile is described. The method involves obtaining a sample of genetic material from the subject. The genetic material is amplified using prime...

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Bibliographische Detailangaben
Hauptverfasser:	Moon, Jihyun, Anderson-Furgeson, James, Kain, Ph.D., James S, Ero, MT, CLS, MBA, Michael P
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A method for determining a subject's risk for developing chronic kidney disease (CKD) combined with determining a subject's pharmacogenomic (PGX) profile is described. The method involves obtaining a sample of genetic material from the subject. The genetic material is amplified using primers specific for the genes underlying CKD and PGX. The DNA sequence of the amplified genetic material is determined and compared with the human reference genome sequence. One or more DNA sequence alterations in the amplified genetic material not present in the human reference genome sequence determines the PGX profile of the subject and may indicate that the subject is at risk for developing CKD.