HETEROCYCLIC PAD4 INHIBITORS

HETEROCYCLIC PAD4 INHIBITORS

The disclosure generally relates to substituted heterocyclic compounds of Formula (Ia), which are inhibitors of PAD4, method for preparing these compounds, pharmaceutical compositions comprising these compounds and use of these compounds in the treatment of a disease or a disorder associated with PA...

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Bibliographische Detailangaben
Hauptverfasser: Selvakumar, Kumaravel, Agarwal, Piyush, Gormisky, Paul E, Paidi, Venkatram, Tino, Joseph A, Zhu, Xiao, Gardner, Daniel S, Cherney, Robert J, Thangathirupathy, Srinivasan, Alajangi, Tirupathi Rao, Duncia, John V, Mahadevu, Krishna, Zhu, Zhengdong, Miao, Guobin, Sura, Mallikarjun Reddy, Seletsky, Boris M, Sistla, Ramesh Kumar, Dhar, T. G. Murali, Morampudi, Ooha, Antropow, Alyssa H, Panda, Manoranjan, Nair, Jalathi S, Ross, Audrey Graham, Subbiah Karuppiah, Arul Mozhi, Cuervo, Julio Herman, Kumar Cm, Vijaya, Niu, Deqiang
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The disclosure generally relates to substituted heterocyclic compounds of Formula (Ia), which are inhibitors of PAD4, method for preparing these compounds, pharmaceutical compositions comprising these compounds and use of these compounds in the treatment of a disease or a disorder associated with PAD4 enzyme activity.