PHARMACEUTICAL COMPOSITION OF LIPID NANOPARTICLE FOR DELIVERING NUCLEIC ACID DRUG CONTAINING TREHALOSE DERIVATIVE AND NOVEL STRUCTURE-MAINTAINING LIPID COMPOUND

PHARMACEUTICAL COMPOSITION OF LIPID NANOPARTICLE FOR DELIVERING NUCLEIC ACID DRUG CONTAINING TREHALOSE DERIVATIVE AND NOVEL STRUCTURE-MAINTAINING LIPID COMPOUND

Disclosed is a novel composition of lipid nanoparticles for stabilizing a nucleic acid drug and enhancing delivery in vivo. Lipid nanoparticles include a nucleic acid drug and a lipid, and the nucleic acid includes all of mRNA-based vaccines, RNA for immune boosters, miRNA, siRNA, pDNA, antisense OD...

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Hauptverfasser: KANG, Taek, JEON, Byung Sun, KEUM, Gyo Chang, BAE, Seo Hyeon, NAM, Jae Hwan, BANG, Eun Kyoung, LEE, An Soo
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator KANG, Taek
JEON, Byung Sun
KEUM, Gyo Chang
BAE, Seo Hyeon
NAM, Jae Hwan
BANG, Eun Kyoung
LEE, An Soo
description Disclosed is a novel composition of lipid nanoparticles for stabilizing a nucleic acid drug and enhancing delivery in vivo. Lipid nanoparticles include a nucleic acid drug and a lipid, and the nucleic acid includes all of mRNA-based vaccines, RNA for immune boosters, miRNA, siRNA, pDNA, antisense ODN, and pDNA. The lipid of nanoparticles includes a trehalose-based lipid, an ionizable lipid, a phospholipid, a PEG-lipid, and a structure-maintaining lipid. The structure-maintaining lipid provides a composition that can replace commonly used cholesterol with a lithocholic acid derivative, a glycyrrhetinic acid derivative, or a diosgenin derivative. The lipid nanoparticles can be used as a vaccine or therapeutic agent, depending on the type of nucleic acid drug that is used.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title PHARMACEUTICAL COMPOSITION OF LIPID NANOPARTICLE FOR DELIVERING NUCLEIC ACID DRUG CONTAINING TREHALOSE DERIVATIVE AND NOVEL STRUCTURE-MAINTAINING LIPID COMPOUND
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