3,4-DIHYDRO-2,7-NAPHTHYRIDINE-1,6(2H,7H)-DIONES AS MEK INHIBITORS
The invention relates to a compound of Formula Ior a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compo...
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| creator | DAHLKE, Joshua Ryan CLARK, Wesley Dewitt MORENO, David Austin KNAPP, Ellen Margaret DOERNER BARBOUR, Patrick Michael ALLEN, Shelley COWDREY, Connor James BLAKE, James Francis O'LEARY, Jacob Matthew REN, Li KELLUM, Alex Andrew BLANCHE, Sydney Taylor WITKOS, Faith Elizabeth BOYS, Mark Laurence |
| description | The invention relates to a compound of Formula Ior a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione. |
| format | Patent |
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The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230420&DB=EPODOC&CC=US&NR=2023120188A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230420&DB=EPODOC&CC=US&NR=2023120188A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DAHLKE, Joshua Ryan</creatorcontrib><creatorcontrib>CLARK, Wesley Dewitt</creatorcontrib><creatorcontrib>MORENO, David Austin</creatorcontrib><creatorcontrib>KNAPP, Ellen Margaret</creatorcontrib><creatorcontrib>DOERNER BARBOUR, Patrick Michael</creatorcontrib><creatorcontrib>ALLEN, Shelley</creatorcontrib><creatorcontrib>COWDREY, Connor James</creatorcontrib><creatorcontrib>BLAKE, James Francis</creatorcontrib><creatorcontrib>O'LEARY, Jacob Matthew</creatorcontrib><creatorcontrib>REN, Li</creatorcontrib><creatorcontrib>KELLUM, Alex Andrew</creatorcontrib><creatorcontrib>BLANCHE, Sydney Taylor</creatorcontrib><creatorcontrib>WITKOS, Faith Elizabeth</creatorcontrib><creatorcontrib>BOYS, Mark Laurence</creatorcontrib><title>3,4-DIHYDRO-2,7-NAPHTHYRIDINE-1,6(2H,7H)-DIONES AS MEK INHIBITORS</title><description>The invention relates to a compound of Formula Ior a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. 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The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHA01jHRdfH0iHQJ8tc10jHX9XMM8AjxiAzydPH0c9U11DHTMPLQMffQBCry93MNVnAMVvB19Vbw9PPwdPIM8Q8K5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8aHBRgZGxoZGBoYWFo6GxsSpAgDdHSqc</recordid><startdate>20230420</startdate><enddate>20230420</enddate><creator>DAHLKE, Joshua Ryan</creator><creator>CLARK, Wesley Dewitt</creator><creator>MORENO, David Austin</creator><creator>KNAPP, Ellen Margaret</creator><creator>DOERNER BARBOUR, Patrick Michael</creator><creator>ALLEN, Shelley</creator><creator>COWDREY, Connor James</creator><creator>BLAKE, James Francis</creator><creator>O'LEARY, Jacob Matthew</creator><creator>REN, Li</creator><creator>KELLUM, Alex Andrew</creator><creator>BLANCHE, Sydney Taylor</creator><creator>WITKOS, Faith Elizabeth</creator><creator>BOYS, Mark Laurence</creator><scope>EVB</scope></search><sort><creationdate>20230420</creationdate><title>3,4-DIHYDRO-2,7-NAPHTHYRIDINE-1,6(2H,7H)-DIONES AS MEK INHIBITORS</title><author>DAHLKE, Joshua Ryan ; CLARK, Wesley Dewitt ; MORENO, David Austin ; KNAPP, Ellen Margaret ; DOERNER BARBOUR, Patrick Michael ; ALLEN, Shelley ; COWDREY, Connor James ; BLAKE, James Francis ; O'LEARY, Jacob Matthew ; REN, Li ; KELLUM, Alex Andrew ; BLANCHE, Sydney Taylor ; WITKOS, Faith Elizabeth ; BOYS, Mark Laurence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2023120188A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DAHLKE, Joshua Ryan</creatorcontrib><creatorcontrib>CLARK, Wesley Dewitt</creatorcontrib><creatorcontrib>MORENO, David Austin</creatorcontrib><creatorcontrib>KNAPP, Ellen Margaret</creatorcontrib><creatorcontrib>DOERNER BARBOUR, Patrick Michael</creatorcontrib><creatorcontrib>ALLEN, Shelley</creatorcontrib><creatorcontrib>COWDREY, Connor James</creatorcontrib><creatorcontrib>BLAKE, James Francis</creatorcontrib><creatorcontrib>O'LEARY, Jacob Matthew</creatorcontrib><creatorcontrib>REN, Li</creatorcontrib><creatorcontrib>KELLUM, Alex Andrew</creatorcontrib><creatorcontrib>BLANCHE, Sydney Taylor</creatorcontrib><creatorcontrib>WITKOS, Faith Elizabeth</creatorcontrib><creatorcontrib>BOYS, Mark Laurence</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DAHLKE, Joshua Ryan</au><au>CLARK, Wesley Dewitt</au><au>MORENO, David Austin</au><au>KNAPP, Ellen Margaret</au><au>DOERNER BARBOUR, Patrick Michael</au><au>ALLEN, Shelley</au><au>COWDREY, Connor James</au><au>BLAKE, James Francis</au><au>O'LEARY, Jacob Matthew</au><au>REN, Li</au><au>KELLUM, Alex Andrew</au><au>BLANCHE, Sydney Taylor</au><au>WITKOS, Faith Elizabeth</au><au>BOYS, Mark Laurence</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>3,4-DIHYDRO-2,7-NAPHTHYRIDINE-1,6(2H,7H)-DIONES AS MEK INHIBITORS</title><date>2023-04-20</date><risdate>2023</risdate><abstract>The invention relates to a compound of Formula Ior a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 3,4-DIHYDRO-2,7-NAPHTHYRIDINE-1,6(2H,7H)-DIONES AS MEK INHIBITORS |
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