SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE

SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE

The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignanc...

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Hauptverfasser: Jones, William M, Krawczuk, Paul J, Eccles, Wendy, Hack, Michael D, Lebsack, Alec D, Pippel, Daniel J, Rovira, Alexander R, Wolin, Ronald L
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator Jones, William M
Krawczuk, Paul J
Eccles, Wendy
Hack, Michael D
Lebsack, Alec D
Pippel, Daniel J
Rovira, Alexander R
Wolin, Ronald L
description The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE
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