NEUTRALIZING MONO-SPECIFIC IgY ANTIBODIES TO INHIBIT OR TREAT SARS-COV-2 CORONAVIRUS INFECTION

NEUTRALIZING MONO-SPECIFIC IgY ANTIBODIES TO INHIBIT OR TREAT SARS-COV-2 CORONAVIRUS INFECTION

Methods for producing mono-specific immunoglobin Y (IgY) antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are disclosed. IgY antibodies are found in birds and can be isolated from egg yolk of chicken eggs. Hens are immunized with a SARS-CoV-2 spike protein comprising a...

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Hauptverfasser: EL-KAFRAWY, Sherif Ali, AZHAR, Esam Ibraheem, ABBAS, Aymn Talat
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Sprache:eng
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CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator EL-KAFRAWY, Sherif Ali
AZHAR, Esam Ibraheem
ABBAS, Aymn Talat
description Methods for producing mono-specific immunoglobin Y (IgY) antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are disclosed. IgY antibodies are found in birds and can be isolated from egg yolk of chicken eggs. Hens are immunized with a SARS-CoV-2 spike protein comprising an ACE2 receptor binding domain (RBD). IgY antibodies against the RBD are isolated from eggs laid by the hens. The isolated RBD-IgY antibodies were tested in vitro in mammalian cells, wherein the RBD-IgY blocked SARS-CoV-2 infection of the cells. A pharmaceutical composition comprising the mono-specific IgY antibodies can be used to inhibit or treat COOVID-19, the SARS-CoV-2 infection. IgY antibodies are generally regarded as safe and offer various production and treatment advantages when compared to mammalian antibodies.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title NEUTRALIZING MONO-SPECIFIC IgY ANTIBODIES TO INHIBIT OR TREAT SARS-COV-2 CORONAVIRUS INFECTION
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