HETEROCYCLIC INHIBITORS OF ENPP1

HETEROCYCLIC INHIBITORS OF ENPP1

The present disclosure relates generally to inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to triazolopyrimidine and imidazolopyrimidine in...

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Hauptverfasser: BETTIGOLE, Sarah, VAN DER HEIJDEN, Gydo, COGAN, Derek A, VIJAYACHANDRAN, Prashanna, SU, Michael, VAN BERKOM, Leon, NIECZYPOR, Piotr
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ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator BETTIGOLE, Sarah
VAN DER HEIJDEN, Gydo
COGAN, Derek A
VIJAYACHANDRAN, Prashanna
SU, Michael
VAN BERKOM, Leon
NIECZYPOR, Piotr
description The present disclosure relates generally to inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to triazolopyrimidine and imidazolopyrimidine inhibitors of ENPP1 and methods of their use for treating disease mediated by ENPP1.
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title HETEROCYCLIC INHIBITORS OF ENPP1
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