SYNTHESIS OF REVERSIBLE NUCLEOTIDE TERMINATORS BY IN-SITU THIO-ALKYL GROUP TRANSFER FOR USE IN DNA SEQUENCING BY SYNTHESIS

The invention is directed to a method for production of a deoxynucleotide triphosphate according to general formula (7)wherein B is a nucleobase and R is an alkyl group having 1 to 4 carbon atoms and n is an integer from 1 to 10 by reaction of reaction precursor of compound 6wherein R1, R2 and R3 ar...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	Soliman, Sameh, MARMA, Mong Sano, GUAN, Xiao-Pei, PERBOST, Michel
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS
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