NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST GLUCOSYLCERAMIDE SYNTHASE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESSES FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

Provided are a compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof, wherein the compound having a chromane, isochrom...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	JOO, Jae-Eun, LEE, Eui-Chul, KIM, Dong-Hoon, KWON, Sool-Ki, SHIN, Seung-Yub, HAN, Tae-Dong
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	JOO, Jae-Eun LEE, Eui-Chul KIM, Dong-Hoon KWON, Sool-Ki SHIN, Seung-Yub HAN, Tae-Dong
description	Provided are a compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof, wherein the compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2023002380A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2023002380A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2023002380A13</originalsourceid><addsrcrecordid>eNqNjrFKBEEMhrexEPUdAteesN41trlsdicwOzNMsgtbHYeMlejB-Z6-krNqIVYWIfnh-5JcNx8hzuyB4pjiFDoFh7OEASQ4OYjFvACSySxWhwElqMHgJ4q6eOKMo3QMugRzqAwxQ3KYRySeTAi9X3XiZHjwlUNvYI4zx34LKUdiVVboVy9zwryerkAlR94Chu7Pvu9HVUxi0K-QRX9Lt83V8-nlUu5--k2z6dnI3Zfz27Fczqen8lrej5Pu2t2-rfXY4sP-f9QnVctTbQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST GLUCOSYLCERAMIDE SYNTHASE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESSES FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME</title><source>esp@cenet</source><creator>JOO, Jae-Eun ; LEE, Eui-Chul ; KIM, Dong-Hoon ; KWON, Sool-Ki ; SHIN, Seung-Yub ; HAN, Tae-Dong</creator><creatorcontrib>JOO, Jae-Eun ; LEE, Eui-Chul ; KIM, Dong-Hoon ; KWON, Sool-Ki ; SHIN, Seung-Yub ; HAN, Tae-Dong</creatorcontrib><description>Provided are a compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof, wherein the compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230105&DB=EPODOC&CC=US&NR=2023002380A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230105&DB=EPODOC&CC=US&NR=2023002380A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JOO, Jae-Eun</creatorcontrib><creatorcontrib>LEE, Eui-Chul</creatorcontrib><creatorcontrib>KIM, Dong-Hoon</creatorcontrib><creatorcontrib>KWON, Sool-Ki</creatorcontrib><creatorcontrib>SHIN, Seung-Yub</creatorcontrib><creatorcontrib>HAN, Tae-Dong</creatorcontrib><title>NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST GLUCOSYLCERAMIDE SYNTHASE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESSES FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME</title><description>Provided are a compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof, wherein the compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjrFKBEEMhrexEPUdAteesN41trlsdicwOzNMsgtbHYeMlejB-Z6-krNqIVYWIfnh-5JcNx8hzuyB4pjiFDoFh7OEASQ4OYjFvACSySxWhwElqMHgJ4q6eOKMo3QMugRzqAwxQ3KYRySeTAi9X3XiZHjwlUNvYI4zx34LKUdiVVboVy9zwryerkAlR94Chu7Pvu9HVUxi0K-QRX9Lt83V8-nlUu5--k2z6dnI3Zfz27Fczqen8lrej5Pu2t2-rfXY4sP-f9QnVctTbQ</recordid><startdate>20230105</startdate><enddate>20230105</enddate><creator>JOO, Jae-Eun</creator><creator>LEE, Eui-Chul</creator><creator>KIM, Dong-Hoon</creator><creator>KWON, Sool-Ki</creator><creator>SHIN, Seung-Yub</creator><creator>HAN, Tae-Dong</creator><scope>EVB</scope></search><sort><creationdate>20230105</creationdate><title>NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST GLUCOSYLCERAMIDE SYNTHASE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESSES FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME</title><author>JOO, Jae-Eun ; LEE, Eui-Chul ; KIM, Dong-Hoon ; KWON, Sool-Ki ; SHIN, Seung-Yub ; HAN, Tae-Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2023002380A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>JOO, Jae-Eun</creatorcontrib><creatorcontrib>LEE, Eui-Chul</creatorcontrib><creatorcontrib>KIM, Dong-Hoon</creatorcontrib><creatorcontrib>KWON, Sool-Ki</creatorcontrib><creatorcontrib>SHIN, Seung-Yub</creatorcontrib><creatorcontrib>HAN, Tae-Dong</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JOO, Jae-Eun</au><au>LEE, Eui-Chul</au><au>KIM, Dong-Hoon</au><au>KWON, Sool-Ki</au><au>SHIN, Seung-Yub</au><au>HAN, Tae-Dong</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST GLUCOSYLCERAMIDE SYNTHASE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESSES FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME</title><date>2023-01-05</date><risdate>2023</risdate><abstract>Provided are a compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof, wherein the compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.</abstract><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	eng
recordid	cdi_epo_espacenet_US2023002380A1
source	esp@cenet
subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
title	NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST GLUCOSYLCERAMIDE SYNTHASE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESSES FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-16T09%3A03%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=JOO,%20Jae-Eun&rft.date=2023-01-05&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2023002380A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true