RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF

RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF

The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Kumar, Puneet, Yamamoto, Kana, Liu, Jun, Semple, Joseph E, Hong, Sam, Sadagopan, Magesh, Ullman, Brett R, Schmitt, Jennifer C
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator Kumar, Puneet
Yamamoto, Kana
Liu, Jun
Semple, Joseph E
Hong, Sam
Sadagopan, Magesh
Ullman, Brett R
Schmitt, Jennifer C
description The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2023000996A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2023000996A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2023000996A13</originalsourceid><addsrcrecordid>eNrjZLAMcgxwdAt19vRTcHEN8gxzDPEMc1Vw9vcN8A_1cwlWcPRzUfB1DfHwB7L93RRCg10VQjxcg1z93XgYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXxosJGBkbGBgYGlpZmjoTFxqgAzFims</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF</title><source>esp@cenet</source><creator>Kumar, Puneet ; Yamamoto, Kana ; Liu, Jun ; Semple, Joseph E ; Hong, Sam ; Sadagopan, Magesh ; Ullman, Brett R ; Schmitt, Jennifer C</creator><creatorcontrib>Kumar, Puneet ; Yamamoto, Kana ; Liu, Jun ; Semple, Joseph E ; Hong, Sam ; Sadagopan, Magesh ; Ullman, Brett R ; Schmitt, Jennifer C</creatorcontrib><description>The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.</description><language>eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20230105&amp;DB=EPODOC&amp;CC=US&amp;NR=2023000996A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20230105&amp;DB=EPODOC&amp;CC=US&amp;NR=2023000996A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Kumar, Puneet</creatorcontrib><creatorcontrib>Yamamoto, Kana</creatorcontrib><creatorcontrib>Liu, Jun</creatorcontrib><creatorcontrib>Semple, Joseph E</creatorcontrib><creatorcontrib>Hong, Sam</creatorcontrib><creatorcontrib>Sadagopan, Magesh</creatorcontrib><creatorcontrib>Ullman, Brett R</creatorcontrib><creatorcontrib>Schmitt, Jennifer C</creatorcontrib><title>RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF</title><description>The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAMcgxwdAt19vRTcHEN8gxzDPEMc1Vw9vcN8A_1cwlWcPRzUfB1DfHwB7L93RRCg10VQjxcg1z93XgYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXxosJGBkbGBgYGlpZmjoTFxqgAzFims</recordid><startdate>20230105</startdate><enddate>20230105</enddate><creator>Kumar, Puneet</creator><creator>Yamamoto, Kana</creator><creator>Liu, Jun</creator><creator>Semple, Joseph E</creator><creator>Hong, Sam</creator><creator>Sadagopan, Magesh</creator><creator>Ullman, Brett R</creator><creator>Schmitt, Jennifer C</creator><scope>EVB</scope></search><sort><creationdate>20230105</creationdate><title>RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF</title><author>Kumar, Puneet ; Yamamoto, Kana ; Liu, Jun ; Semple, Joseph E ; Hong, Sam ; Sadagopan, Magesh ; Ullman, Brett R ; Schmitt, Jennifer C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2023000996A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2023</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>Kumar, Puneet</creatorcontrib><creatorcontrib>Yamamoto, Kana</creatorcontrib><creatorcontrib>Liu, Jun</creatorcontrib><creatorcontrib>Semple, Joseph E</creatorcontrib><creatorcontrib>Hong, Sam</creatorcontrib><creatorcontrib>Sadagopan, Magesh</creatorcontrib><creatorcontrib>Ullman, Brett R</creatorcontrib><creatorcontrib>Schmitt, Jennifer C</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Kumar, Puneet</au><au>Yamamoto, Kana</au><au>Liu, Jun</au><au>Semple, Joseph E</au><au>Hong, Sam</au><au>Sadagopan, Magesh</au><au>Ullman, Brett R</au><au>Schmitt, Jennifer C</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF</title><date>2023-01-05</date><risdate>2023</risdate><abstract>The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_epo_espacenet_US2023000996A1
source esp@cenet
subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T18%3A12%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Kumar,%20Puneet&rft.date=2023-01-05&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2023000996A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true