PYRIDOPYRIMIDINONE COMPOUNDS AND APPLICATIONS THEREOF

The present disclosure provides the Pyridopyrimidinone compounds having the structure represented by the general Formula (II) and applications thereof. Studies have shown that the compounds provided by the present disclosure can effectively inhibit the KRAS G12C mutation. KRAS mutation accounts for...

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Hauptverfasser: CAI, Xiong, LIN, Mingsheng, FAN, Fushun, LIU, Bin, QIAN, Changgeng, HE, Qijie, QING, Yuanhui, LIU, Yiting, WENG, Yunwo, FENG, Qiao
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creator CAI, Xiong
LIN, Mingsheng
FAN, Fushun
LIU, Bin
QIAN, Changgeng
HE, Qijie
QING, Yuanhui
LIU, Yiting
WENG, Yunwo
FENG, Qiao
description The present disclosure provides the Pyridopyrimidinone compounds having the structure represented by the general Formula (II) and applications thereof. Studies have shown that the compounds provided by the present disclosure can effectively inhibit the KRAS G12C mutation. KRAS mutation accounts for a large proportion of tumors, and currently there is no approved drug for its treatment. The compounds provided by the present disclosure have the potential to become a therapeutic medicine for malignant tumors (especially non-small cell lung cancer (NSCLC) and colorectal cancer) haboring KRAS G12C mutation, and have great application value.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title PYRIDOPYRIMIDINONE COMPOUNDS AND APPLICATIONS THEREOF
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