INGESTIBLE DEVICE WITH DELIVERY MEMBER DETACHMENT

An ingestible device is disclosed suitable for swallowing into a lumen of a gastrointestinal tract of a patient, the lumen having a lumen wall. The ingestible device (100, 200) comprises: a capsule (110, 120), a delivery member (130) being shaped to penetrate tissue of a lumen wall and having a tissue penetrating end and a trailing end, the delivery member (130) comprising a therapeutic payload, a ram (150) attached relative to the delivery member (130) at the trailing end; and an actuator (140) coupled to the ram (150) and having a first configuration and a second configuration, the delivery member (130) being retained by the ram (150) within the capsule (110, 120) when the actuator (140) is in the first configuration, wherein the delivery member (130) is configured to be advanced from the capsule (110, 120) and into the lumen wall by movement of the actuator (140) from the first configuration to the second configuration such that the delivery member (130) moves along a predefined trajectory. The ram (150) is configured for being tilted relative to the predefined trajectory upon the actuator (140) moving into the second configuration to detach at least a portion of the delivery member (130) from the ram (150) such that the detached portion of the delivery member (130) remains within the lumen wall to release therapeutic payload.