HYDROPHILIC LINKERS FOR MULTIVALENT PEPTIDE CONJUGATES
The present disclosure is directed to peptide-polymer conjugates utilizing hydrophilic linkers, and their use in treating diseases or disorders. In one embodiment, the present invention provides a conjugate of Formula I: (X-Y)n-Z Formula (I) wherein each X is independently a peptide having a molecul...
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| creator | BRIER, Livia Wilz JACKSON, Wesley M TWITE, Amy A |
| description | The present disclosure is directed to peptide-polymer conjugates utilizing hydrophilic linkers, and their use in treating diseases or disorders. In one embodiment, the present invention provides a conjugate of Formula I: (X-Y)n-Z Formula (I) wherein each X is independently a peptide having a molecular weight of from about 5 kDa to about 200 kDa; each Y is independently a hydrophilic linker; Z is a biocompatible polymer having a molecular weight of from about 0.1 MDa to about 3 MDa; and subscript n is an integer from 10 to 1000. |
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In one embodiment, the present invention provides a conjugate of Formula I: (X-Y)n-Z Formula (I) wherein each X is independently a peptide having a molecular weight of from about 5 kDa to about 200 kDa; each Y is independently a hydrophilic linker; Z is a biocompatible polymer having a molecular weight of from about 0.1 MDa to about 3 MDa; and subscript n is an integer from 10 to 1000.</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220811&DB=EPODOC&CC=US&NR=2022251185A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220811&DB=EPODOC&CC=US&NR=2022251185A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BRIER, Livia Wilz</creatorcontrib><creatorcontrib>JACKSON, Wesley M</creatorcontrib><creatorcontrib>TWITE, Amy A</creatorcontrib><title>HYDROPHILIC LINKERS FOR MULTIVALENT PEPTIDE CONJUGATES</title><description>The present disclosure is directed to peptide-polymer conjugates utilizing hydrophilic linkers, and their use in treating diseases or disorders. In one embodiment, the present invention provides a conjugate of Formula I: (X-Y)n-Z Formula (I) wherein each X is independently a peptide having a molecular weight of from about 5 kDa to about 200 kDa; each Y is independently a hydrophilic linker; Z is a biocompatible polymer having a molecular weight of from about 0.1 MDa to about 3 MDa; and subscript n is an integer from 10 to 1000.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDziHQJ8g_w8PTxdFbw8fTzdg0KVnDzD1LwDfUJ8Qxz9HH1C1EIcA0I8XRxVXD29_MKdXcMcQ3mYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXxocFGBkZGRqaGhhamjobGxKkCAOREKTo</recordid><startdate>20220811</startdate><enddate>20220811</enddate><creator>BRIER, Livia Wilz</creator><creator>JACKSON, Wesley M</creator><creator>TWITE, Amy A</creator><scope>EVB</scope></search><sort><creationdate>20220811</creationdate><title>HYDROPHILIC LINKERS FOR MULTIVALENT PEPTIDE CONJUGATES</title><author>BRIER, Livia Wilz ; JACKSON, Wesley M ; TWITE, Amy A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2022251185A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BRIER, Livia Wilz</creatorcontrib><creatorcontrib>JACKSON, Wesley M</creatorcontrib><creatorcontrib>TWITE, Amy A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BRIER, Livia Wilz</au><au>JACKSON, Wesley M</au><au>TWITE, Amy A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HYDROPHILIC LINKERS FOR MULTIVALENT PEPTIDE CONJUGATES</title><date>2022-08-11</date><risdate>2022</risdate><abstract>The present disclosure is directed to peptide-polymer conjugates utilizing hydrophilic linkers, and their use in treating diseases or disorders. In one embodiment, the present invention provides a conjugate of Formula I: (X-Y)n-Z Formula (I) wherein each X is independently a peptide having a molecular weight of from about 5 kDa to about 200 kDa; each Y is independently a hydrophilic linker; Z is a biocompatible polymer having a molecular weight of from about 0.1 MDa to about 3 MDa; and subscript n is an integer from 10 to 1000.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HYDROPHILIC LINKERS FOR MULTIVALENT PEPTIDE CONJUGATES |
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