NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF

The present invention provides a new class of non-immunosupressive FK506 analogs which are FKBP-selective, small-molecule BMP agonists with modest potency therepeutics for tissue repair and regeneration. Also disclosed herein are methods for making and use of these compounds.

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Hauptverfasser: Sun, Zhaoli, Qi, Le, Liu, Jun O, Peng, Hanjing, Guo, Zufeng, Peiffer, Brandon J, Wang, Yuefan, Ahmadi, Ali
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creator Sun, Zhaoli
Qi, Le
Liu, Jun O
Peng, Hanjing
Guo, Zufeng
Peiffer, Brandon J
Wang, Yuefan
Ahmadi, Ali
description The present invention provides a new class of non-immunosupressive FK506 analogs which are FKBP-selective, small-molecule BMP agonists with modest potency therepeutics for tissue repair and regeneration. Also disclosed herein are methods for making and use of these compounds.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF
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