ENGINEERING OF AN ANTIBODY FOR TUMOR-SELECTIVE BINDING OF CD47

Antibodies are provided which comprise at least one Fab portion that binds CD47 and at least one Fab portion that binds the tumor associated antigen (TAA) CD20; wherein the Fab portion that binds CD47 exhibits low affinity for CD47; and, wherein the Fab portion that binds CD20 exhibits high affinity...

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Hauptverfasser:	CHO, Ho, JOHNSON, Jeffrey, HADJIVASSILIOU, Haralambos, SUN, Jeonghoon, ZHU, Dan, ACHARYA, Sharmistha, HARIHARAN, Kandasamy
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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