ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR 1 (ROR1)
Provided are receptor tyrosine kinase-like orphan receptor 1 (ROR1)-binding molecules, in particular, to human antibodies specific for ROR1, including antibody fragments. The present disclosure further relates to recombinant receptors, including chimeric antigen receptors (CARs) that contain such an...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | CHEN, Aye JIANG, Yue OH, Yeonjoo BELMONT, Brian JEFFERY, Eric BEDI, Samriti HAUSKINS, Collin AMIN, Rupesh GOLDFLESS, Stephen Jacob SIERRA, Catherine WILLIAMS, Madeline BAILEY, Jenna COSTA, Andreia |
| description | Provided are receptor tyrosine kinase-like orphan receptor 1 (ROR1)-binding molecules, in particular, to human antibodies specific for ROR1, including antibody fragments. The present disclosure further relates to recombinant receptors, including chimeric antigen receptors (CARs) that contain such antibodies or fragments, and polynucleotides that encode the antibodies, antigen-binding fragments or receptors specific for ROR1. The disclosure further relates to genetically engineered cells, containing such ROR1-binding proteins and receptors, and related methods and uses thereof in adoptive cell therapy. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2022096651A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2022096651A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2022096651A13</originalsourceid><addsrcrecordid>eNqNi70KwjAURrs4iPoOF1x0EJqKBceY3phLNQk3cXAqReLkT6G-PyqIrk4Hzvm-YXaVNtLGVYQBpK1AGdojk4K336IFRoU-Og4QPCrSr6QdfzXEI7tAFqEmKwPCjmoEx97I3xcEzNixmI-zwbm99Gny4SibaozKLFJ3b1Lftad0S4_mEIq8KPJ1Wa6EFMv_Vk_gTTeA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR 1 (ROR1)</title><source>esp@cenet</source><creator>CHEN, Aye ; JIANG, Yue ; OH, Yeonjoo ; BELMONT, Brian ; JEFFERY, Eric ; BEDI, Samriti ; HAUSKINS, Collin ; AMIN, Rupesh ; GOLDFLESS, Stephen Jacob ; SIERRA, Catherine ; WILLIAMS, Madeline ; BAILEY, Jenna ; COSTA, Andreia</creator><creatorcontrib>CHEN, Aye ; JIANG, Yue ; OH, Yeonjoo ; BELMONT, Brian ; JEFFERY, Eric ; BEDI, Samriti ; HAUSKINS, Collin ; AMIN, Rupesh ; GOLDFLESS, Stephen Jacob ; SIERRA, Catherine ; WILLIAMS, Madeline ; BAILEY, Jenna ; COSTA, Andreia</creatorcontrib><description>Provided are receptor tyrosine kinase-like orphan receptor 1 (ROR1)-binding molecules, in particular, to human antibodies specific for ROR1, including antibody fragments. The present disclosure further relates to recombinant receptors, including chimeric antigen receptors (CARs) that contain such antibodies or fragments, and polynucleotides that encode the antibodies, antigen-binding fragments or receptors specific for ROR1. The disclosure further relates to genetically engineered cells, containing such ROR1-binding proteins and receptors, and related methods and uses thereof in adoptive cell therapy.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220331&DB=EPODOC&CC=US&NR=2022096651A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220331&DB=EPODOC&CC=US&NR=2022096651A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHEN, Aye</creatorcontrib><creatorcontrib>JIANG, Yue</creatorcontrib><creatorcontrib>OH, Yeonjoo</creatorcontrib><creatorcontrib>BELMONT, Brian</creatorcontrib><creatorcontrib>JEFFERY, Eric</creatorcontrib><creatorcontrib>BEDI, Samriti</creatorcontrib><creatorcontrib>HAUSKINS, Collin</creatorcontrib><creatorcontrib>AMIN, Rupesh</creatorcontrib><creatorcontrib>GOLDFLESS, Stephen Jacob</creatorcontrib><creatorcontrib>SIERRA, Catherine</creatorcontrib><creatorcontrib>WILLIAMS, Madeline</creatorcontrib><creatorcontrib>BAILEY, Jenna</creatorcontrib><creatorcontrib>COSTA, Andreia</creatorcontrib><title>ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR 1 (ROR1)</title><description>Provided are receptor tyrosine kinase-like orphan receptor 1 (ROR1)-binding molecules, in particular, to human antibodies specific for ROR1, including antibody fragments. The present disclosure further relates to recombinant receptors, including chimeric antigen receptors (CARs) that contain such antibodies or fragments, and polynucleotides that encode the antibodies, antigen-binding fragments or receptors specific for ROR1. The disclosure further relates to genetically engineered cells, containing such ROR1-binding proteins and receptors, and related methods and uses thereof in adoptive cell therapy.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi70KwjAURrs4iPoOF1x0EJqKBceY3phLNQk3cXAqReLkT6G-PyqIrk4Hzvm-YXaVNtLGVYQBpK1AGdojk4K336IFRoU-Og4QPCrSr6QdfzXEI7tAFqEmKwPCjmoEx97I3xcEzNixmI-zwbm99Gny4SibaozKLFJ3b1Lftad0S4_mEIq8KPJ1Wa6EFMv_Vk_gTTeA</recordid><startdate>20220331</startdate><enddate>20220331</enddate><creator>CHEN, Aye</creator><creator>JIANG, Yue</creator><creator>OH, Yeonjoo</creator><creator>BELMONT, Brian</creator><creator>JEFFERY, Eric</creator><creator>BEDI, Samriti</creator><creator>HAUSKINS, Collin</creator><creator>AMIN, Rupesh</creator><creator>GOLDFLESS, Stephen Jacob</creator><creator>SIERRA, Catherine</creator><creator>WILLIAMS, Madeline</creator><creator>BAILEY, Jenna</creator><creator>COSTA, Andreia</creator><scope>EVB</scope></search><sort><creationdate>20220331</creationdate><title>ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR 1 (ROR1)</title><author>CHEN, Aye ; JIANG, Yue ; OH, Yeonjoo ; BELMONT, Brian ; JEFFERY, Eric ; BEDI, Samriti ; HAUSKINS, Collin ; AMIN, Rupesh ; GOLDFLESS, Stephen Jacob ; SIERRA, Catherine ; WILLIAMS, Madeline ; BAILEY, Jenna ; COSTA, Andreia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2022096651A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2022</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CHEN, Aye</creatorcontrib><creatorcontrib>JIANG, Yue</creatorcontrib><creatorcontrib>OH, Yeonjoo</creatorcontrib><creatorcontrib>BELMONT, Brian</creatorcontrib><creatorcontrib>JEFFERY, Eric</creatorcontrib><creatorcontrib>BEDI, Samriti</creatorcontrib><creatorcontrib>HAUSKINS, Collin</creatorcontrib><creatorcontrib>AMIN, Rupesh</creatorcontrib><creatorcontrib>GOLDFLESS, Stephen Jacob</creatorcontrib><creatorcontrib>SIERRA, Catherine</creatorcontrib><creatorcontrib>WILLIAMS, Madeline</creatorcontrib><creatorcontrib>BAILEY, Jenna</creatorcontrib><creatorcontrib>COSTA, Andreia</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHEN, Aye</au><au>JIANG, Yue</au><au>OH, Yeonjoo</au><au>BELMONT, Brian</au><au>JEFFERY, Eric</au><au>BEDI, Samriti</au><au>HAUSKINS, Collin</au><au>AMIN, Rupesh</au><au>GOLDFLESS, Stephen Jacob</au><au>SIERRA, Catherine</au><au>WILLIAMS, Madeline</au><au>BAILEY, Jenna</au><au>COSTA, Andreia</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR 1 (ROR1)</title><date>2022-03-31</date><risdate>2022</risdate><abstract>Provided are receptor tyrosine kinase-like orphan receptor 1 (ROR1)-binding molecules, in particular, to human antibodies specific for ROR1, including antibody fragments. The present disclosure further relates to recombinant receptors, including chimeric antigen receptors (CARs) that contain such antibodies or fragments, and polynucleotides that encode the antibodies, antigen-binding fragments or receptors specific for ROR1. The disclosure further relates to genetically engineered cells, containing such ROR1-binding proteins and receptors, and related methods and uses thereof in adoptive cell therapy.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US2022096651A1 |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR 1 (ROR1) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T10%3A53%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=CHEN,%20Aye&rft.date=2022-03-31&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2022096651A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |