ARIPIPRAZOLE PRODRUG COMPOSITION

ARIPIPRAZOLE PRODRUG COMPOSITION

Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm and (b) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particl...

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Hauptverfasser: ZEIDAN, Tarek, HICKEY, Magali, CRESSWELL, Philip, LIVERSIDGE, Elaine, SMITH, Greg, STEINBERG, Brian, PERKIN, Kristopher, MANSER, David
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator ZEIDAN, Tarek
HICKEY, Magali
CRESSWELL, Philip
LIVERSIDGE, Elaine
SMITH, Greg
STEINBERG, Brian
PERKIN, Kristopher
MANSER, David
description Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm and (b) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particles and a free component available for solubilisation of the aripiprazole prodrug. The surface stabilizer to prodrug ratio provides the optimal quantity of free surface stabilizer for the purposes of producing a lead-in formulation. Also described are methods of treatment using the aforementioned composition.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title ARIPIPRAZOLE PRODRUG COMPOSITION
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