MACROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE
The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The inven...
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| creator | Bursulaya, Badry ZHU, Xuefeng WHITEHEAD, Lewis WU, Baogen YAN, Shanshan Jiang, Songchun Azimioara, Mihai NGUYEN, Truc Ngoc OKRAM, Barun MATHISON, Casey Jacob Nelson NIKULIN, Victor Ivanovich PHILLIPS, Dean Paul PATEL, Sejal |
| description | The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders. |
| format | Patent |
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The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. 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The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLD3dXQO8neOdPbxdFZw9vcN8A_1cwlWcPRzUQjxcPUMUggNdlXw9ANxFEKCXB1DfF39QhT83RRcPINdHYNdeRhY0xJzilN5oTQ3g7Kba4izh25qQX58anFBYnJqXmpJfGiwkYGRkYG5oaW5oaOhMXGqABPKKxQ</recordid><startdate>20220310</startdate><enddate>20220310</enddate><creator>Bursulaya, Badry</creator><creator>ZHU, Xuefeng</creator><creator>WHITEHEAD, Lewis</creator><creator>WU, Baogen</creator><creator>YAN, Shanshan</creator><creator>Jiang, Songchun</creator><creator>Azimioara, Mihai</creator><creator>NGUYEN, Truc Ngoc</creator><creator>OKRAM, Barun</creator><creator>MATHISON, Casey Jacob Nelson</creator><creator>NIKULIN, Victor Ivanovich</creator><creator>PHILLIPS, Dean Paul</creator><creator>PATEL, Sejal</creator><scope>EVB</scope></search><sort><creationdate>20220310</creationdate><title>MACROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE</title><author>Bursulaya, Badry ; ZHU, Xuefeng ; WHITEHEAD, Lewis ; WU, Baogen ; YAN, Shanshan ; Jiang, Songchun ; Azimioara, Mihai ; NGUYEN, Truc Ngoc ; OKRAM, Barun ; MATHISON, Casey Jacob Nelson ; NIKULIN, Victor Ivanovich ; PHILLIPS, Dean Paul ; PATEL, Sejal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2022071971A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>Bursulaya, Badry</creatorcontrib><creatorcontrib>ZHU, Xuefeng</creatorcontrib><creatorcontrib>WHITEHEAD, Lewis</creatorcontrib><creatorcontrib>WU, Baogen</creatorcontrib><creatorcontrib>YAN, Shanshan</creatorcontrib><creatorcontrib>Jiang, Songchun</creatorcontrib><creatorcontrib>Azimioara, Mihai</creatorcontrib><creatorcontrib>NGUYEN, Truc Ngoc</creatorcontrib><creatorcontrib>OKRAM, Barun</creatorcontrib><creatorcontrib>MATHISON, Casey Jacob Nelson</creatorcontrib><creatorcontrib>NIKULIN, Victor Ivanovich</creatorcontrib><creatorcontrib>PHILLIPS, Dean Paul</creatorcontrib><creatorcontrib>PATEL, Sejal</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Bursulaya, Badry</au><au>ZHU, Xuefeng</au><au>WHITEHEAD, Lewis</au><au>WU, Baogen</au><au>YAN, Shanshan</au><au>Jiang, Songchun</au><au>Azimioara, Mihai</au><au>NGUYEN, Truc Ngoc</au><au>OKRAM, Barun</au><au>MATHISON, Casey Jacob Nelson</au><au>NIKULIN, Victor Ivanovich</au><au>PHILLIPS, Dean Paul</au><au>PATEL, Sejal</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MACROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE</title><date>2022-03-10</date><risdate>2022</risdate><abstract>The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | MACROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE |
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