POLYMERIC FORMS OF H-NOX PROTEINS

The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Serwer, Laura, Le Moan, Natacha, Kapp, Gregory, Cary, Stephen P. L
Format: Patent
Sprache:eng
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