ANTI-HUMAN NGF ANTIBODIES AND METHODS USING SAME

ANTI-HUMAN NGF ANTIBODIES AND METHODS USING SAME

The invention provides an antibody and/or an antigen binding fragment that binds to NGF, and the amino acid sequences of the heavy chain and light chain variable regions of the antibody. The NGF antibody and/or its antigen binding fragment provided by the invention has high affinity for NGF and can...

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Hauptverfasser: Gao, Yongjuan, Chen, Si, Sun, Bill Nai-Chau, Sun, Cecily Rou-Yun, Li, Qiang, Zheng, Yuncheng, Wang, Zhu
Format: Patent
Sprache:eng
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CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator Gao, Yongjuan
Chen, Si
Sun, Bill Nai-Chau
Sun, Cecily Rou-Yun
Li, Qiang
Zheng, Yuncheng
Wang, Zhu
description The invention provides an antibody and/or an antigen binding fragment that binds to NGF, and the amino acid sequences of the heavy chain and light chain variable regions of the antibody. The NGF antibody and/or its antigen binding fragment provided by the invention has high affinity for NGF and can effectively block the binding between NGF receptor and NGF. This antibody and/or its antigen binding fragment can inhibit the binding activity of NGF and its receptor in vitro, and is suitable for the treatment of pain diseases which are related to the haughty expression or increased expression of NGF.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title ANTI-HUMAN NGF ANTIBODIES AND METHODS USING SAME
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