CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE
A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for t...
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| creator | ZHAO, Robert Yongxin LI, Wenjun SU, Qingyu GUO, Zhixiang HUANG, Yuanyuan YE, Zhicang YANG, Qingliang CAI, Xiang ZUO, Xiaotao TONG, Qianqian ZHAO, Linyao YE, Hangbo PENG, Jie GAI, Shun YANG, Yanlei XU, Jun ZHU, Haifeng JIA, Junxiang ZHOU, Xiaomai GUO, Huihui XU, Yifang LIN, Chen YANG, Chengyu GAO, Shuihong WANG, Chunyan CHAO, Minjun XIE, Hongsheng |
| description | A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease.wherein "" is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker. |
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Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease.wherein "" is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.</abstract><oa>free_for_read</oa></addata></record> |
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| title | CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE |
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