PROCESS FOR THE PREPARATION OF TREPROSTINIL

PROCESS FOR THE PREPARATION OF TREPROSTINIL

Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous for...

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Hauptverfasser: LÁSZLÓFI, István, ALTSACH, Tamás, BUZDER-LANTOS, Péter, KARDOS, Zsuzsanna, ROZSUMBERSZKI, Imre, NAGYNÉ BORKÓ, Ágnes, JUHÁSZ, Imre, HAVASI, Gábor, HORTOBÁGYI, Irén
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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creator LÁSZLÓFI, István
ALTSACH, Tamás
BUZDER-LANTOS, Péter
KARDOS, Zsuzsanna
ROZSUMBERSZKI, Imre
NAGYNÉ BORKÓ, Ágnes
JUHÁSZ, Imre
HAVASI, Gábor
HORTOBÁGYI, Irén
description Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title PROCESS FOR THE PREPARATION OF TREPROSTINIL
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