CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS

The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an aldehyde group obtained from oxidation of a 2-hydroxyethylamine moiety on the CBA. The invention also provides methods of preparin...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	Tavares, Daniel J, Rui, Lingyun, Shizuka, Manami, Miller, Michael Louis, Chari, Ravi V.J, Fishkin, Nathan Elliott, Harris, Luke B
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!