PYRAZOLE AND IMIDAZOLE COMPOUNDS FOR INHIBITION OF IL-17 AND RORGAMMA

PYRAZOLE AND IMIDAZOLE COMPOUNDS FOR INHIBITION OF IL-17 AND RORGAMMA

Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and RORγ. Also pro...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: BOLTON, Gary, BENDER, Christopher F, CAPRATHE, Bradley, HOTEMA, Martha R, JIANG, Xin, KORNBERG, Brian, O'BRIEN, Patrick, VISNICK, Melean, LEE, Chitase
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator BOLTON, Gary
BENDER, Christopher F
CAPRATHE, Bradley
HOTEMA, Martha R
JIANG, Xin
KORNBERG, Brian
O'BRIEN, Patrick
VISNICK, Melean
LEE, Chitase
description Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and RORγ. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2021292281A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2021292281A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2021292281A13</originalsourceid><addsrcrecordid>eNrjZHANiAxyjPL3cVVw9HNR8PT1dIHwnP19A_xD_VyCFdz8gxQ8_Tw8nTxDPP39FPzdFDx9dA3NweqD_IPcHX19HXkYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXxosJGBkaGRpZGRhaGjoTFxqgASByyV</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PYRAZOLE AND IMIDAZOLE COMPOUNDS FOR INHIBITION OF IL-17 AND RORGAMMA</title><source>esp@cenet</source><creator>BOLTON, Gary ; BENDER, Christopher F ; CAPRATHE, Bradley ; HOTEMA, Martha R ; JIANG, Xin ; KORNBERG, Brian ; O'BRIEN, Patrick ; VISNICK, Melean ; LEE, Chitase</creator><creatorcontrib>BOLTON, Gary ; BENDER, Christopher F ; CAPRATHE, Bradley ; HOTEMA, Martha R ; JIANG, Xin ; KORNBERG, Brian ; O'BRIEN, Patrick ; VISNICK, Melean ; LEE, Chitase</creatorcontrib><description>Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and RORγ. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20210923&amp;DB=EPODOC&amp;CC=US&amp;NR=2021292281A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20210923&amp;DB=EPODOC&amp;CC=US&amp;NR=2021292281A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BOLTON, Gary</creatorcontrib><creatorcontrib>BENDER, Christopher F</creatorcontrib><creatorcontrib>CAPRATHE, Bradley</creatorcontrib><creatorcontrib>HOTEMA, Martha R</creatorcontrib><creatorcontrib>JIANG, Xin</creatorcontrib><creatorcontrib>KORNBERG, Brian</creatorcontrib><creatorcontrib>O'BRIEN, Patrick</creatorcontrib><creatorcontrib>VISNICK, Melean</creatorcontrib><creatorcontrib>LEE, Chitase</creatorcontrib><title>PYRAZOLE AND IMIDAZOLE COMPOUNDS FOR INHIBITION OF IL-17 AND RORGAMMA</title><description>Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and RORγ. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHANiAxyjPL3cVVw9HNR8PT1dIHwnP19A_xD_VyCFdz8gxQ8_Tw8nTxDPP39FPzdFDx9dA3NweqD_IPcHX19HXkYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXxosJGBkaGRpZGRhaGjoTFxqgASByyV</recordid><startdate>20210923</startdate><enddate>20210923</enddate><creator>BOLTON, Gary</creator><creator>BENDER, Christopher F</creator><creator>CAPRATHE, Bradley</creator><creator>HOTEMA, Martha R</creator><creator>JIANG, Xin</creator><creator>KORNBERG, Brian</creator><creator>O'BRIEN, Patrick</creator><creator>VISNICK, Melean</creator><creator>LEE, Chitase</creator><scope>EVB</scope></search><sort><creationdate>20210923</creationdate><title>PYRAZOLE AND IMIDAZOLE COMPOUNDS FOR INHIBITION OF IL-17 AND RORGAMMA</title><author>BOLTON, Gary ; BENDER, Christopher F ; CAPRATHE, Bradley ; HOTEMA, Martha R ; JIANG, Xin ; KORNBERG, Brian ; O'BRIEN, Patrick ; VISNICK, Melean ; LEE, Chitase</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2021292281A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>BOLTON, Gary</creatorcontrib><creatorcontrib>BENDER, Christopher F</creatorcontrib><creatorcontrib>CAPRATHE, Bradley</creatorcontrib><creatorcontrib>HOTEMA, Martha R</creatorcontrib><creatorcontrib>JIANG, Xin</creatorcontrib><creatorcontrib>KORNBERG, Brian</creatorcontrib><creatorcontrib>O'BRIEN, Patrick</creatorcontrib><creatorcontrib>VISNICK, Melean</creatorcontrib><creatorcontrib>LEE, Chitase</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BOLTON, Gary</au><au>BENDER, Christopher F</au><au>CAPRATHE, Bradley</au><au>HOTEMA, Martha R</au><au>JIANG, Xin</au><au>KORNBERG, Brian</au><au>O'BRIEN, Patrick</au><au>VISNICK, Melean</au><au>LEE, Chitase</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PYRAZOLE AND IMIDAZOLE COMPOUNDS FOR INHIBITION OF IL-17 AND RORGAMMA</title><date>2021-09-23</date><risdate>2021</risdate><abstract>Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and RORγ. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_epo_espacenet_US2021292281A1
source esp@cenet
subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title PYRAZOLE AND IMIDAZOLE COMPOUNDS FOR INHIBITION OF IL-17 AND RORGAMMA
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T01%3A34%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=BOLTON,%20Gary&rft.date=2021-09-23&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2021292281A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true