FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND PCSK9

The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relat...

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Bibliographische Detailangaben
Hauptverfasser:	LIPOVSEK, Dasa, MIAO, Bowman, LOW, Chee Meng, RAKESTRAW, Ginger C, SITKOFF, Doree F, LO, Ching-Hsiung Frederick, DENHEZ, Fabienne M, DAVIS, Jonathan H, SAEED-KOTHE, Amna, RUSSO, Katie A, CAMPHAUSEN, Ray, MITCHELL, Tracy S, CLOAD, Sharon T, PARKER, Rex A
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.