CARBOXYESTERASE POLYPEPTIDES FOR AMIDE COUPLING

The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyeste...

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Bibliographische Detailangaben
Hauptverfasser: Dorr, Brent, Fuerst, Douglas E, Micklitsch, Christopher Michael, Dellas, Nikki, Zhang, Xiyun, Mitchell, Vesna, Sero, Antoinette, Voladri, Rama, Entwistle, David
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in amidation reactions.