Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use

The invention discloses compounds of Formula (I),wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treati...

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Bibliographische Detailangaben
Hauptverfasser:	Bogdan, Andrew, Couty, Sylvain, Van der Plas, Steven Emiel, Merayo Merayo, Nuria, Desroy, Nicolas, Mai, Thi Thu Trang, Wang, Xueqing, Malagu, Karine Fabienne, Gfesser, Gregory A, Searle, Xenia B, Liu, Bo, Housseman, Christopher Gaëtan, Yeung, Ming C, Picolet, Olivier Laurent, Altenbach, Robert J, Kym, Philip R, Pizzonero, Mathieu Rafaël
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention discloses compounds of Formula (I),wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.