ENGINEERED ACID ALPHA-GLUCOSIDASE VARIANTS
The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides m...
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| creator | Huisman, Gjalt W Silverman, Adam P Alaoui Ismaili, Moulay Hicham Homan, David William Zhu, Yu Dellas, Nikki Lao, Jessica P Chng, Chinping Vroom, Jonathan Botham, Rachel Cathleen Hallows, William Casey |
| description | The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes. |
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In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210624&DB=EPODOC&CC=US&NR=2021189365A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210624&DB=EPODOC&CC=US&NR=2021189365A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Huisman, Gjalt W</creatorcontrib><creatorcontrib>Silverman, Adam P</creatorcontrib><creatorcontrib>Alaoui Ismaili, Moulay Hicham</creatorcontrib><creatorcontrib>Homan, David William</creatorcontrib><creatorcontrib>Zhu, Yu</creatorcontrib><creatorcontrib>Dellas, Nikki</creatorcontrib><creatorcontrib>Lao, Jessica P</creatorcontrib><creatorcontrib>Chng, Chinping</creatorcontrib><creatorcontrib>Vroom, Jonathan</creatorcontrib><creatorcontrib>Botham, Rachel Cathleen</creatorcontrib><creatorcontrib>Hallows, William Casey</creatorcontrib><title>ENGINEERED ACID ALPHA-GLUCOSIDASE VARIANTS</title><description>The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. 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In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | ENGINEERED ACID ALPHA-GLUCOSIDASE VARIANTS |
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