THIENOCYCLIC COMPOUND AND SYNTHESIS METHOD THEREFOR AND APPLICATION THEREOF
Disclosed by the present invention are a thienocyclic compound represented by formula (I), a pharmaceutically acceptable salt or a hydrate thereof, a composition containing the thienocyclic compound, and a preparation method therefor. Further disclosed by the present invention is an application of t...
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| creator | YANG, Junjie YU, Weiwei ZHANG, Xinpei LIU, Mingyao XI, Zaixi ZHANG, Hankun LU, Weiqiang LIU, Wenjuan HU, Longlong LIN, Xianhua |
| description | Disclosed by the present invention are a thienocyclic compound represented by formula (I), a pharmaceutically acceptable salt or a hydrate thereof, a composition containing the thienocyclic compound, and a preparation method therefor. Further disclosed by the present invention is an application of the thienocyclic compound as a prostaglandin EP4 receptor antagonist that is used for preventing and treating prostaglandin PGE2-mediated diseases, comprising malignant tumors, autoimmune diseases inflammation, pain and osteoarthritis. |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | THIENOCYCLIC COMPOUND AND SYNTHESIS METHOD THEREFOR AND APPLICATION THEREOF |
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