BISPECIFIC ANTIBODY FOR ICOS AND PD-L1
Multispecific antibody in mAb2 format, comprising an ICOS-binding Fab region and a PD-L1-binding Fcab region. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours. Combination therapy including antibody to another immune checkpoint molecule such as PD-1 and...
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| creator | MCCOURT, Matthew John TUNA, Mihriban WOLLERTON VAN HORCK, Francisca ARKINSTALL, Stephen John BADR, Fadi FIEHLER, Ryan CAMPBELL, Jamie Iain AKELE, Frederik SAINSON, Richard Charles Alfred FAROUDI, Mustapha |
| description | Multispecific antibody in mAb2 format, comprising an ICOS-binding Fab region and a PD-L1-binding Fcab region. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours. Combination therapy including antibody to another immune checkpoint molecule such as PD-1 and CTLA-4, in addition to anti-ICOS and anti-PD-L1. |
| format | Patent |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | BISPECIFIC ANTIBODY FOR ICOS AND PD-L1 |
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