CYCLIC PEPTIDE ANTIBIOTICS

CYCLIC PEPTIDE ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment...

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Bibliographische Detailangaben
Hauptverfasser: HANAN, Emily J, CASTANEDO, Georgette, FU, Yuhong, GIBBONS, Paul, YUEN, Po-Wai, GARLAND, Keira, SMITH, Peter Andrew, PASTOR, Richard, WU, Guosheng, BRAUN, Marie Gabrielle, CHENG, Yunxing
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.