NOVEL SYNTHESIS METHOD FOR THE PREPARATION OF DIBENZOATE COMPOUNDS, SUCH AS 4-[BENZOYL(METHYL)AMINO]PENTANE-2-YL DIBENZOATE

NOVEL SYNTHESIS METHOD FOR THE PREPARATION OF DIBENZOATE COMPOUNDS, SUCH AS 4-[BENZOYL(METHYL)AMINO]PENTANE-2-YL DIBENZOATE

The present invention relates to a process for synthesis of a compound according to Formula (A): wherein R1 is a substituted or unsubstituted aryl having 6 to 20 carbon atoms; preferably substituted or unsubstituted phenyl; R2 is a straight or branched alkyl having 1 to 12 carbon atoms; and R3 is a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Abhyankar, Shirish Shrikant, Shaikh, Abbas-Alli Ghudubhai, Sainani, Jaiprakash Brijlal, Gunasekaran, Sivalingam
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator Abhyankar, Shirish Shrikant
Shaikh, Abbas-Alli Ghudubhai
Sainani, Jaiprakash Brijlal
Gunasekaran, Sivalingam
description The present invention relates to a process for synthesis of a compound according to Formula (A): wherein R1 is a substituted or unsubstituted aryl having 6 to 20 carbon atoms; preferably substituted or unsubstituted phenyl; R2 is a straight or branched alkyl having 1 to 12 carbon atoms; and R3 is a straight or branched alkyl having 1 to 12 carbon atoms; starting from a di-keto compound according to Formula (B) wherein R3 is as shown above, which compound is converted into a ketoenamine compound according to Formula (C) wherein R2 and R3 are as shown above, which ketoenamine compound is then reduced to an amino alcohol according to Formula (D), wherein R2 and R3 are as shown above, that is subsequently converted into a compound according to Formula (A): characterized in that the ketoenamine is reduced into an amino alcohol using a nickel aluminium alloy in an aqueous solution of an inorganic base.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2020239407A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2020239407A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2020239407A13</originalsourceid><addsrcrecordid>eNqNjLEKwjAURbs4iPoPD1wUDNS2II6xfaWBNC80qRBFSpE4iRbq5s9bxcFR7nDhnssZB09Fe5RgnLIFGmGgRFtQBjlVMCygK9S84laQAsohEztUB-IWIaVSU60yswJTpwVwAwk7frCTi7fGySUvhaKTRmW5QhYxJ38U02B0aa-9n317EsxztGnBfHdvfN-1Z3_zj6Y2UTgk3ibhhq_j_14vY4I8Bg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>NOVEL SYNTHESIS METHOD FOR THE PREPARATION OF DIBENZOATE COMPOUNDS, SUCH AS 4-[BENZOYL(METHYL)AMINO]PENTANE-2-YL DIBENZOATE</title><source>esp@cenet</source><creator>Abhyankar, Shirish Shrikant ; Shaikh, Abbas-Alli Ghudubhai ; Sainani, Jaiprakash Brijlal ; Gunasekaran, Sivalingam</creator><creatorcontrib>Abhyankar, Shirish Shrikant ; Shaikh, Abbas-Alli Ghudubhai ; Sainani, Jaiprakash Brijlal ; Gunasekaran, Sivalingam</creatorcontrib><description>The present invention relates to a process for synthesis of a compound according to Formula (A): wherein R1 is a substituted or unsubstituted aryl having 6 to 20 carbon atoms; preferably substituted or unsubstituted phenyl; R2 is a straight or branched alkyl having 1 to 12 carbon atoms; and R3 is a straight or branched alkyl having 1 to 12 carbon atoms; starting from a di-keto compound according to Formula (B) wherein R3 is as shown above, which compound is converted into a ketoenamine compound according to Formula (C) wherein R2 and R3 are as shown above, which ketoenamine compound is then reduced to an amino alcohol according to Formula (D), wherein R2 and R3 are as shown above, that is subsequently converted into a compound according to Formula (A): characterized in that the ketoenamine is reduced into an amino alcohol using a nickel aluminium alloy in an aqueous solution of an inorganic base.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20200730&amp;DB=EPODOC&amp;CC=US&amp;NR=2020239407A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20200730&amp;DB=EPODOC&amp;CC=US&amp;NR=2020239407A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Abhyankar, Shirish Shrikant</creatorcontrib><creatorcontrib>Shaikh, Abbas-Alli Ghudubhai</creatorcontrib><creatorcontrib>Sainani, Jaiprakash Brijlal</creatorcontrib><creatorcontrib>Gunasekaran, Sivalingam</creatorcontrib><title>NOVEL SYNTHESIS METHOD FOR THE PREPARATION OF DIBENZOATE COMPOUNDS, SUCH AS 4-[BENZOYL(METHYL)AMINO]PENTANE-2-YL DIBENZOATE</title><description>The present invention relates to a process for synthesis of a compound according to Formula (A): wherein R1 is a substituted or unsubstituted aryl having 6 to 20 carbon atoms; preferably substituted or unsubstituted phenyl; R2 is a straight or branched alkyl having 1 to 12 carbon atoms; and R3 is a straight or branched alkyl having 1 to 12 carbon atoms; starting from a di-keto compound according to Formula (B) wherein R3 is as shown above, which compound is converted into a ketoenamine compound according to Formula (C) wherein R2 and R3 are as shown above, which ketoenamine compound is then reduced to an amino alcohol according to Formula (D), wherein R2 and R3 are as shown above, that is subsequently converted into a compound according to Formula (A): characterized in that the ketoenamine is reduced into an amino alcohol using a nickel aluminium alloy in an aqueous solution of an inorganic base.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLEKwjAURbs4iPoPD1wUDNS2II6xfaWBNC80qRBFSpE4iRbq5s9bxcFR7nDhnssZB09Fe5RgnLIFGmGgRFtQBjlVMCygK9S84laQAsohEztUB-IWIaVSU60yswJTpwVwAwk7frCTi7fGySUvhaKTRmW5QhYxJ38U02B0aa-9n317EsxztGnBfHdvfN-1Z3_zj6Y2UTgk3ibhhq_j_14vY4I8Bg</recordid><startdate>20200730</startdate><enddate>20200730</enddate><creator>Abhyankar, Shirish Shrikant</creator><creator>Shaikh, Abbas-Alli Ghudubhai</creator><creator>Sainani, Jaiprakash Brijlal</creator><creator>Gunasekaran, Sivalingam</creator><scope>EVB</scope></search><sort><creationdate>20200730</creationdate><title>NOVEL SYNTHESIS METHOD FOR THE PREPARATION OF DIBENZOATE COMPOUNDS, SUCH AS 4-[BENZOYL(METHYL)AMINO]PENTANE-2-YL DIBENZOATE</title><author>Abhyankar, Shirish Shrikant ; Shaikh, Abbas-Alli Ghudubhai ; Sainani, Jaiprakash Brijlal ; Gunasekaran, Sivalingam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2020239407A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2020</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>Abhyankar, Shirish Shrikant</creatorcontrib><creatorcontrib>Shaikh, Abbas-Alli Ghudubhai</creatorcontrib><creatorcontrib>Sainani, Jaiprakash Brijlal</creatorcontrib><creatorcontrib>Gunasekaran, Sivalingam</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Abhyankar, Shirish Shrikant</au><au>Shaikh, Abbas-Alli Ghudubhai</au><au>Sainani, Jaiprakash Brijlal</au><au>Gunasekaran, Sivalingam</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL SYNTHESIS METHOD FOR THE PREPARATION OF DIBENZOATE COMPOUNDS, SUCH AS 4-[BENZOYL(METHYL)AMINO]PENTANE-2-YL DIBENZOATE</title><date>2020-07-30</date><risdate>2020</risdate><abstract>The present invention relates to a process for synthesis of a compound according to Formula (A): wherein R1 is a substituted or unsubstituted aryl having 6 to 20 carbon atoms; preferably substituted or unsubstituted phenyl; R2 is a straight or branched alkyl having 1 to 12 carbon atoms; and R3 is a straight or branched alkyl having 1 to 12 carbon atoms; starting from a di-keto compound according to Formula (B) wherein R3 is as shown above, which compound is converted into a ketoenamine compound according to Formula (C) wherein R2 and R3 are as shown above, which ketoenamine compound is then reduced to an amino alcohol according to Formula (D), wherein R2 and R3 are as shown above, that is subsequently converted into a compound according to Formula (A): characterized in that the ketoenamine is reduced into an amino alcohol using a nickel aluminium alloy in an aqueous solution of an inorganic base.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_epo_espacenet_US2020239407A1
source esp@cenet
subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title NOVEL SYNTHESIS METHOD FOR THE PREPARATION OF DIBENZOATE COMPOUNDS, SUCH AS 4-[BENZOYL(METHYL)AMINO]PENTANE-2-YL DIBENZOATE
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T12%3A11%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Abhyankar,%20Shirish%20Shrikant&rft.date=2020-07-30&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2020239407A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true