Modified Latency Associated Protein Construct

Modified Latency Associated Protein Construct

The present invention provides a fusion protein comprising a latency associated peptide (LAP), a pharmaceutically active agent and an amino acid sequence comprising a dimerisation domain, wherein the LAP and the pharmaceutically active agent are connected by an amino acid sequence comprising a prole...

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Hauptverfasser: Muhammad, Hawzheen, Gould, David James, Chernajovsky, Yuti, Adams, Gillian, Mullen, Lisa
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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creator Muhammad, Hawzheen
Gould, David James
Chernajovsky, Yuti
Adams, Gillian
Mullen, Lisa
description The present invention provides a fusion protein comprising a latency associated peptide (LAP), a pharmaceutically active agent and an amino acid sequence comprising a dimerisation domain, wherein the LAP and the pharmaceutically active agent are connected by an amino acid sequence comprising a proleolytic cleavage site. Also provided are nucleic acids enclosing such fusion proteins, process for their preparation, pharmaceutical compositions, kits and uses thereof in medicine.
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ORGANIC CHEMISTRY
PEPTIDES
title Modified Latency Associated Protein Construct
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