A PHARMACEUTICAL COMPOSITION COMPRISING ROSUVASTATIN AND EZETIMIBE AND A PREPARATION METHOD THEREOF

A PHARMACEUTICAL COMPOSITION COMPRISING ROSUVASTATIN AND EZETIMIBE AND A PREPARATION METHOD THEREOF

The invention relates to a pharmaceutical composition comprising the active ingredients rosuvastatin of formula I, with the systematic name (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid or its pharmaceutically acceptable...

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Hauptverfasser: DAMMER, Ondrej, MIKES, Petr, PROKOPOVA, Alena, SVOBODOVA, Jaroslava
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator DAMMER, Ondrej
MIKES, Petr
PROKOPOVA, Alena
SVOBODOVA, Jaroslava
description The invention relates to a pharmaceutical composition comprising the active ingredients rosuvastatin of formula I, with the systematic name (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid or its pharmaceutically acceptable salts, esters, hydrates or solvates, and ezetimibe of formula II, with the systematic name (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one or its pharmaceutically acceptable salts, esters, hydrates or solvates, as well as a preparation method of this pharmaceutical composition. The weight ratio of the layers is 1:2 to 2:1.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title A PHARMACEUTICAL COMPOSITION COMPRISING ROSUVASTATIN AND EZETIMIBE AND A PREPARATION METHOD THEREOF
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