Compounds & Methods for the Enhanced Degradation of Targeted Proteins & Other Polypeptides by an E3 Ubiquitin Ligase

The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In p...

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Hauptverfasser:	JORGENSEN, WILLIAM L, HARLING, JOHN DAVID, LE, JOELLE, CREWS, CRAIG M, TAE, HYUN-SEOP, ROTH, ANKE G, GAREISS, PETER C, MIAH, AFJAL HUSSAIN, CAMPOS, SEBASTIEN ANDRE, SMITH, IAN EDWARD DAVID, HOYER, DENTON WADE, VAN MOLLE, INGE, MICHEL, JULIEN, GUSTAFSON, JEFFREY, CIULLI, ALESSIO, BUCKLEY, DENNIS
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS STEROIDS VINEGAR WINE
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