SIRT4 LIPOAMIDASE ACTIVITY AND USES THEREOF

SIRT4 LIPOAMIDASE ACTIVITY AND USES THEREOF

The present application demonstrates that sirtuin 4 (SIRT4) acts as a cellular lipoamidase that negatively regulates pyruvate dehydrogenase complex (PDHC) activity through hydrolysis of its lipoamide cofactors.

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Hauptverfasser: Mathias, Rommel A, Shenk, Thomas, Cristea, IIeana M, Oberstein, Adam, Greco, Todd M
Format: Patent
Sprache:eng
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INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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creator Mathias, Rommel A
Shenk, Thomas
Cristea, IIeana M
Oberstein, Adam
Greco, Todd M
description The present application demonstrates that sirtuin 4 (SIRT4) acts as a cellular lipoamidase that negatively regulates pyruvate dehydrogenase complex (PDHC) activity through hydrolysis of its lipoamide cofactors.
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subjects INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
title SIRT4 LIPOAMIDASE ACTIVITY AND USES THEREOF
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