Processes for the Preparation of SGLT-2 Inhibitors, Intermediates Thereof
The present invention relates to novel, improved processes for the preparation of sodium glucose co-transporter 2 (SGLT-2) inhibitors and novel intermediates thereof. More particularly, the present invention relates to a novel, improved process for the preparation of gliflozin compounds such as empa...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | Narani, Chandra Prakash Mundla, Maha Vishnu Chintaginjala, Laxmi Narasimha Varaprasad Gunukula, Suresh Kumar Vure, Prasad Malyala, Sridhar Chittiboyina, Bala Yellaiah Bellam, Prabhakar Dantham, Sowmya Samireddy, Hemalatha Reddy Kale, Pooja |
| description | The present invention relates to novel, improved processes for the preparation of sodium glucose co-transporter 2 (SGLT-2) inhibitors and novel intermediates thereof. More particularly, the present invention relates to a novel, improved process for the preparation of gliflozin compounds such as empagliflozin and dapagliflozin, intermediates thereof. The product obtained from the processes of present invention may be amorphous or crystalline, or in the form of amorphous/crystalline solid dispersions/solutions with pharmaceutically acceptable polymers and preparation process thereof. Also, the products obtained from the present invention may be used for the preparation of medicaments for the prevention and/or treatment of diseases and conditions associated with SGLT-2 inhibition. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2018346502A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2018346502A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2018346502A13</originalsourceid><addsrcrecordid>eNrjZPAMKMpPTi0uTi1WSMsvUijJSFUIKEotSCxKLMnMz1PIT1MIdvcJ0TVS8MzLyEzKLMkvKtYBsktSi3JTUzITS4D6QjJSi1Lz03gYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXxosJGBoYWxiZmpgZGjoTFxqgA_rjS2</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Processes for the Preparation of SGLT-2 Inhibitors, Intermediates Thereof</title><source>esp@cenet</source><creator>Narani, Chandra Prakash ; Mundla, Maha Vishnu ; Chintaginjala, Laxmi Narasimha Varaprasad ; Gunukula, Suresh Kumar ; Vure, Prasad ; Malyala, Sridhar ; Chittiboyina, Bala Yellaiah ; Bellam, Prabhakar ; Dantham, Sowmya ; Samireddy, Hemalatha Reddy ; Kale, Pooja</creator><creatorcontrib>Narani, Chandra Prakash ; Mundla, Maha Vishnu ; Chintaginjala, Laxmi Narasimha Varaprasad ; Gunukula, Suresh Kumar ; Vure, Prasad ; Malyala, Sridhar ; Chittiboyina, Bala Yellaiah ; Bellam, Prabhakar ; Dantham, Sowmya ; Samireddy, Hemalatha Reddy ; Kale, Pooja</creatorcontrib><description>The present invention relates to novel, improved processes for the preparation of sodium glucose co-transporter 2 (SGLT-2) inhibitors and novel intermediates thereof. More particularly, the present invention relates to a novel, improved process for the preparation of gliflozin compounds such as empagliflozin and dapagliflozin, intermediates thereof. The product obtained from the processes of present invention may be amorphous or crystalline, or in the form of amorphous/crystalline solid dispersions/solutions with pharmaceutically acceptable polymers and preparation process thereof. Also, the products obtained from the present invention may be used for the preparation of medicaments for the prevention and/or treatment of diseases and conditions associated with SGLT-2 inhibition.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; APPARATUS THEREFOR ; CHEMISTRY ; DERIVATIVES THEREOF ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SUGARS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181206&DB=EPODOC&CC=US&NR=2018346502A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181206&DB=EPODOC&CC=US&NR=2018346502A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Narani, Chandra Prakash</creatorcontrib><creatorcontrib>Mundla, Maha Vishnu</creatorcontrib><creatorcontrib>Chintaginjala, Laxmi Narasimha Varaprasad</creatorcontrib><creatorcontrib>Gunukula, Suresh Kumar</creatorcontrib><creatorcontrib>Vure, Prasad</creatorcontrib><creatorcontrib>Malyala, Sridhar</creatorcontrib><creatorcontrib>Chittiboyina, Bala Yellaiah</creatorcontrib><creatorcontrib>Bellam, Prabhakar</creatorcontrib><creatorcontrib>Dantham, Sowmya</creatorcontrib><creatorcontrib>Samireddy, Hemalatha Reddy</creatorcontrib><creatorcontrib>Kale, Pooja</creatorcontrib><title>Processes for the Preparation of SGLT-2 Inhibitors, Intermediates Thereof</title><description>The present invention relates to novel, improved processes for the preparation of sodium glucose co-transporter 2 (SGLT-2) inhibitors and novel intermediates thereof. More particularly, the present invention relates to a novel, improved process for the preparation of gliflozin compounds such as empagliflozin and dapagliflozin, intermediates thereof. The product obtained from the processes of present invention may be amorphous or crystalline, or in the form of amorphous/crystalline solid dispersions/solutions with pharmaceutically acceptable polymers and preparation process thereof. Also, the products obtained from the present invention may be used for the preparation of medicaments for the prevention and/or treatment of diseases and conditions associated with SGLT-2 inhibition.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAMKMpPTi0uTi1WSMsvUijJSFUIKEotSCxKLMnMz1PIT1MIdvcJ0TVS8MzLyEzKLMkvKtYBsktSi3JTUzITS4D6QjJSi1Lz03gYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXxosJGBoYWxiZmpgZGjoTFxqgA_rjS2</recordid><startdate>20181206</startdate><enddate>20181206</enddate><creator>Narani, Chandra Prakash</creator><creator>Mundla, Maha Vishnu</creator><creator>Chintaginjala, Laxmi Narasimha Varaprasad</creator><creator>Gunukula, Suresh Kumar</creator><creator>Vure, Prasad</creator><creator>Malyala, Sridhar</creator><creator>Chittiboyina, Bala Yellaiah</creator><creator>Bellam, Prabhakar</creator><creator>Dantham, Sowmya</creator><creator>Samireddy, Hemalatha Reddy</creator><creator>Kale, Pooja</creator><scope>EVB</scope></search><sort><creationdate>20181206</creationdate><title>Processes for the Preparation of SGLT-2 Inhibitors, Intermediates Thereof</title><author>Narani, Chandra Prakash ; Mundla, Maha Vishnu ; Chintaginjala, Laxmi Narasimha Varaprasad ; Gunukula, Suresh Kumar ; Vure, Prasad ; Malyala, Sridhar ; Chittiboyina, Bala Yellaiah ; Bellam, Prabhakar ; Dantham, Sowmya ; Samireddy, Hemalatha Reddy ; Kale, Pooja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2018346502A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2018</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>Narani, Chandra Prakash</creatorcontrib><creatorcontrib>Mundla, Maha Vishnu</creatorcontrib><creatorcontrib>Chintaginjala, Laxmi Narasimha Varaprasad</creatorcontrib><creatorcontrib>Gunukula, Suresh Kumar</creatorcontrib><creatorcontrib>Vure, Prasad</creatorcontrib><creatorcontrib>Malyala, Sridhar</creatorcontrib><creatorcontrib>Chittiboyina, Bala Yellaiah</creatorcontrib><creatorcontrib>Bellam, Prabhakar</creatorcontrib><creatorcontrib>Dantham, Sowmya</creatorcontrib><creatorcontrib>Samireddy, Hemalatha Reddy</creatorcontrib><creatorcontrib>Kale, Pooja</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Narani, Chandra Prakash</au><au>Mundla, Maha Vishnu</au><au>Chintaginjala, Laxmi Narasimha Varaprasad</au><au>Gunukula, Suresh Kumar</au><au>Vure, Prasad</au><au>Malyala, Sridhar</au><au>Chittiboyina, Bala Yellaiah</au><au>Bellam, Prabhakar</au><au>Dantham, Sowmya</au><au>Samireddy, Hemalatha Reddy</au><au>Kale, Pooja</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Processes for the Preparation of SGLT-2 Inhibitors, Intermediates Thereof</title><date>2018-12-06</date><risdate>2018</risdate><abstract>The present invention relates to novel, improved processes for the preparation of sodium glucose co-transporter 2 (SGLT-2) inhibitors and novel intermediates thereof. More particularly, the present invention relates to a novel, improved process for the preparation of gliflozin compounds such as empagliflozin and dapagliflozin, intermediates thereof. The product obtained from the processes of present invention may be amorphous or crystalline, or in the form of amorphous/crystalline solid dispersions/solutions with pharmaceutically acceptable polymers and preparation process thereof. Also, the products obtained from the present invention may be used for the preparation of medicaments for the prevention and/or treatment of diseases and conditions associated with SGLT-2 inhibition.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US2018346502A1 |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY DERIVATIVES THEREOF GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS |
| title | Processes for the Preparation of SGLT-2 Inhibitors, Intermediates Thereof |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T01%3A44%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Narani,%20Chandra%20Prakash&rft.date=2018-12-06&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2018346502A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |