Antibodies Targeted to Fungal Cell Wall Polysaccharides

Antibodies Targeted to Fungal Cell Wall Polysaccharides

A compound comprising one or more polysaccharide moieties each independently represented by the formula β(1→4)-[GlcNH-R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an ac...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: MICHON, Francis, COMER, Frank, REN, Kuishu, WOHLSTADTER, Samuel J
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
METALLURGY
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
PEPTIDES
POLYSACCHARIDES
THEIR PREPARATION OR CHEMICAL WORKING-UP
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator MICHON, Francis
COMER, Frank
REN, Kuishu
WOHLSTADTER, Samuel J
description A compound comprising one or more polysaccharide moieties each independently represented by the formula β(1→4)-[GlcNH-R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2018251573A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2018251573A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2018251573A13</originalsourceid><addsrcrecordid>eNrjZDB3zCvJTMpPyUwtVghJLEpPLUlNUSjJV3ArzUtPzFFwTs3JUQhPBBIB-TmVxYnJyRmJRZkpqcU8DKxpiTnFqbxQmptB2c01xNlDN7UgPz61uCAxOTUvtSQ-NNjIwNDCyNTQ1NzY0dCYOFUAVkMudg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Antibodies Targeted to Fungal Cell Wall Polysaccharides</title><source>esp@cenet</source><creator>MICHON, Francis ; COMER, Frank ; REN, Kuishu ; WOHLSTADTER, Samuel J</creator><creatorcontrib>MICHON, Francis ; COMER, Frank ; REN, Kuishu ; WOHLSTADTER, Samuel J</creatorcontrib><description>A compound comprising one or more polysaccharide moieties each independently represented by the formula β(1→4)-[GlcNH-R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.</description><language>eng</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; DERIVATIVES THEREOF ; METALLURGY ; ORGANIC CHEMISTRY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PEPTIDES ; POLYSACCHARIDES ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20180906&amp;DB=EPODOC&amp;CC=US&amp;NR=2018251573A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20180906&amp;DB=EPODOC&amp;CC=US&amp;NR=2018251573A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MICHON, Francis</creatorcontrib><creatorcontrib>COMER, Frank</creatorcontrib><creatorcontrib>REN, Kuishu</creatorcontrib><creatorcontrib>WOHLSTADTER, Samuel J</creatorcontrib><title>Antibodies Targeted to Fungal Cell Wall Polysaccharides</title><description>A compound comprising one or more polysaccharide moieties each independently represented by the formula β(1→4)-[GlcNH-R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.</description><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>DERIVATIVES THEREOF</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>PEPTIDES</subject><subject>POLYSACCHARIDES</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB3zCvJTMpPyUwtVghJLEpPLUlNUSjJV3ArzUtPzFFwTs3JUQhPBBIB-TmVxYnJyRmJRZkpqcU8DKxpiTnFqbxQmptB2c01xNlDN7UgPz61uCAxOTUvtSQ-NNjIwNDCyNTQ1NzY0dCYOFUAVkMudg</recordid><startdate>20180906</startdate><enddate>20180906</enddate><creator>MICHON, Francis</creator><creator>COMER, Frank</creator><creator>REN, Kuishu</creator><creator>WOHLSTADTER, Samuel J</creator><scope>EVB</scope></search><sort><creationdate>20180906</creationdate><title>Antibodies Targeted to Fungal Cell Wall Polysaccharides</title><author>MICHON, Francis ; COMER, Frank ; REN, Kuishu ; WOHLSTADTER, Samuel J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2018251573A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>DERIVATIVES THEREOF</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>PEPTIDES</topic><topic>POLYSACCHARIDES</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>MICHON, Francis</creatorcontrib><creatorcontrib>COMER, Frank</creatorcontrib><creatorcontrib>REN, Kuishu</creatorcontrib><creatorcontrib>WOHLSTADTER, Samuel J</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MICHON, Francis</au><au>COMER, Frank</au><au>REN, Kuishu</au><au>WOHLSTADTER, Samuel J</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Antibodies Targeted to Fungal Cell Wall Polysaccharides</title><date>2018-09-06</date><risdate>2018</risdate><abstract>A compound comprising one or more polysaccharide moieties each independently represented by the formula β(1→4)-[GlcNH-R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_epo_espacenet_US2018251573A1
source esp@cenet
subjects CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
METALLURGY
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
PEPTIDES
POLYSACCHARIDES
THEIR PREPARATION OR CHEMICAL WORKING-UP
title Antibodies Targeted to Fungal Cell Wall Polysaccharides
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T14%3A52%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=MICHON,%20Francis&rft.date=2018-09-06&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2018251573A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true