FIXED-DOSE COMBINATIONS OF ANTIVIRAL COMPOUNDS
The present disclosure is directed to compositions comprising blended materials comprising a substantially crystalline HCV nucleotide polymerase inhibitor; a first solid dispersion formulation, which comprises an HCV NS5a inhibitor or a pharmaceutically acceptable salt thereof, one or more pharmaceu...
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| creator | Marinaro, William A Kuiper, Jesse Lee DiNunzio, James McKelvey, Craig Alfred Marota, Melanie J |
| description | The present disclosure is directed to compositions comprising blended materials comprising a substantially crystalline HCV nucleotide polymerase inhibitor; a first solid dispersion formulation, which comprises an HCV NS5a inhibitor or a pharmaceutically acceptable salt thereof, one or more pharmaceutically acceptable polymers or a mixture thereof, and optionally one or more pharmaceutically acceptable surfactants or a mixture thereof, and optionally one or more excipients, and a second solid dispersion formulation, which comprises an HCV NS3 inhibitor or a pharmaceutically acceptable salt thereof, one or more pharmaceutically acceptable polymers or a mixture thereof, and optionally one or more pharmaceutically acceptable surfactants or a mixture thereof, and optionally one or more excipients. The present disclosure is also directed to oral dosage forms, such as tablets or capsules comprising the disclosed blended compositions comprising the disclosed solid dispersion formulations, and the methods for making these solid dispersion formulations, and pharmaceutical compositions. |
| format | Patent |
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The present disclosure is also directed to oral dosage forms, such as tablets or capsules comprising the disclosed blended compositions comprising the disclosed solid dispersion formulations, and the methods for making these solid dispersion formulations, and pharmaceutical compositions.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNBz84xwddF18Q92VXD293Xy9HMM8fT3C1bwd1Nw9AvxDPMMcvQByQT4h_q5BPMwsKYl5hSn8kJpbgZlN9cQZw_d1IL8-NTigsTk1LzUkvjQYCMDQwsjIwsLIwtHQ2PiVAEAh1Em4A</recordid><startdate>20180816</startdate><enddate>20180816</enddate><creator>Marinaro, William A</creator><creator>Kuiper, Jesse Lee</creator><creator>DiNunzio, James</creator><creator>McKelvey, Craig Alfred</creator><creator>Marota, Melanie J</creator><scope>EVB</scope></search><sort><creationdate>20180816</creationdate><title>FIXED-DOSE COMBINATIONS OF ANTIVIRAL COMPOUNDS</title><author>Marinaro, William A ; Kuiper, Jesse Lee ; DiNunzio, James ; McKelvey, Craig Alfred ; Marota, Melanie J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2018228828A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2018</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>Marinaro, William A</creatorcontrib><creatorcontrib>Kuiper, Jesse Lee</creatorcontrib><creatorcontrib>DiNunzio, James</creatorcontrib><creatorcontrib>McKelvey, Craig Alfred</creatorcontrib><creatorcontrib>Marota, Melanie J</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Marinaro, William A</au><au>Kuiper, Jesse Lee</au><au>DiNunzio, James</au><au>McKelvey, Craig Alfred</au><au>Marota, Melanie J</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FIXED-DOSE COMBINATIONS OF ANTIVIRAL COMPOUNDS</title><date>2018-08-16</date><risdate>2018</risdate><abstract>The present disclosure is directed to compositions comprising blended materials comprising a substantially crystalline HCV nucleotide polymerase inhibitor; a first solid dispersion formulation, which comprises an HCV NS5a inhibitor or a pharmaceutically acceptable salt thereof, one or more pharmaceutically acceptable polymers or a mixture thereof, and optionally one or more pharmaceutically acceptable surfactants or a mixture thereof, and optionally one or more excipients, and a second solid dispersion formulation, which comprises an HCV NS3 inhibitor or a pharmaceutically acceptable salt thereof, one or more pharmaceutically acceptable polymers or a mixture thereof, and optionally one or more pharmaceutically acceptable surfactants or a mixture thereof, and optionally one or more excipients. The present disclosure is also directed to oral dosage forms, such as tablets or capsules comprising the disclosed blended compositions comprising the disclosed solid dispersion formulations, and the methods for making these solid dispersion formulations, and pharmaceutical compositions.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | FIXED-DOSE COMBINATIONS OF ANTIVIRAL COMPOUNDS |
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