COMPOSITIONS AND METHODS FOR DETECTING CANCER CELLS IN A TISSUE SAMPLE
This invention is directed to methods for the facile and accurate identification of cancer cells in a tissue sample, such as a surgical field. In particular, the compositions and methods employ conjugates comprising pro-fluorescent fluorescein based moieties bound to folic or pteroic acid targeting...
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| creator | HESSLER, III, Theodore Keshishian, Craig FANTE, John PARIZA, Richard SWISS, Gerald F MORIARTY, Robert M WHITE, David |
| description | This invention is directed to methods for the facile and accurate identification of cancer cells in a tissue sample, such as a surgical field. In particular, the compositions and methods employ conjugates comprising pro-fluorescent fluorescein based moieties bound to folic or pteroic acid targeting moiety optionally through a linker. The pro-fluorescent fluorescein based moieties are non-fluorescent but capable of being rendered fluorescent by intracellular processes. The conjugates are employed to detect cancer cells that overexpress folic acid receptors thereby providing for differential accumulation of these conjugates in these cells. |
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In particular, the compositions and methods employ conjugates comprising pro-fluorescent fluorescein based moieties bound to folic or pteroic acid targeting moiety optionally through a linker. The pro-fluorescent fluorescein based moieties are non-fluorescent but capable of being rendered fluorescent by intracellular processes. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PHYSICS TESTING |
| title | COMPOSITIONS AND METHODS FOR DETECTING CANCER CELLS IN A TISSUE SAMPLE |
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