MODIFIED DNASE AND USES THEREOF
Modified DNase I protein in which one or more amino acids of a DNase I protein are modified non-cellularly, are provided. The modified DNase I protein exhibits a DNA hydrolytic activity in the presence of actin and an improved DNA hydrolytic activity compared to a homologous non-modified DNase I pro...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | SHAALTIEL, Yoseph RUDERFER, Ilya UGORTSEV, Yulia NETA, Hagit GELLEY, Sivan CHEN ZELTSBURG, Lilach FUX, Liat LAVEE LAVIAD, Elad SHULMAN, Avidor |
| description | Modified DNase I protein in which one or more amino acids of a DNase I protein are modified non-cellularly, are provided. The modified DNase I protein exhibits a DNA hydrolytic activity in the presence of actin and an improved DNA hydrolytic activity compared to a homologous non-modified DNase I protein. Processes of preparing the modified DNase I protein and uses thereof in, for example, reducing a DNA content in sputum and/or in treating a disease or condition associated with excess extracellular DNA in a fluid, secretion or tissue of a subject, are also provided. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2018112201A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2018112201A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2018112201A13</originalsourceid><addsrcrecordid>eNrjZJD39XfxdPN0dVFw8XMMdlVw9HNRCA12DVYI8XANcvV342FgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8aHBRgaGFoaGRkDK0dCYOFUAOLMiKg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>MODIFIED DNASE AND USES THEREOF</title><source>esp@cenet</source><creator>SHAALTIEL, Yoseph ; RUDERFER, Ilya ; UGORTSEV, Yulia ; NETA, Hagit ; GELLEY, Sivan ; CHEN ZELTSBURG, Lilach ; FUX, Liat ; LAVEE LAVIAD, Elad ; SHULMAN, Avidor</creator><creatorcontrib>SHAALTIEL, Yoseph ; RUDERFER, Ilya ; UGORTSEV, Yulia ; NETA, Hagit ; GELLEY, Sivan ; CHEN ZELTSBURG, Lilach ; FUX, Liat ; LAVEE LAVIAD, Elad ; SHULMAN, Avidor</creatorcontrib><description>Modified DNase I protein in which one or more amino acids of a DNase I protein are modified non-cellularly, are provided. The modified DNase I protein exhibits a DNA hydrolytic activity in the presence of actin and an improved DNA hydrolytic activity compared to a homologous non-modified DNase I protein. Processes of preparing the modified DNase I protein and uses thereof in, for example, reducing a DNA content in sputum and/or in treating a disease or condition associated with excess extracellular DNA in a fluid, secretion or tissue of a subject, are also provided.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180426&DB=EPODOC&CC=US&NR=2018112201A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180426&DB=EPODOC&CC=US&NR=2018112201A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SHAALTIEL, Yoseph</creatorcontrib><creatorcontrib>RUDERFER, Ilya</creatorcontrib><creatorcontrib>UGORTSEV, Yulia</creatorcontrib><creatorcontrib>NETA, Hagit</creatorcontrib><creatorcontrib>GELLEY, Sivan</creatorcontrib><creatorcontrib>CHEN ZELTSBURG, Lilach</creatorcontrib><creatorcontrib>FUX, Liat</creatorcontrib><creatorcontrib>LAVEE LAVIAD, Elad</creatorcontrib><creatorcontrib>SHULMAN, Avidor</creatorcontrib><title>MODIFIED DNASE AND USES THEREOF</title><description>Modified DNase I protein in which one or more amino acids of a DNase I protein are modified non-cellularly, are provided. The modified DNase I protein exhibits a DNA hydrolytic activity in the presence of actin and an improved DNA hydrolytic activity compared to a homologous non-modified DNase I protein. Processes of preparing the modified DNase I protein and uses thereof in, for example, reducing a DNA content in sputum and/or in treating a disease or condition associated with excess extracellular DNA in a fluid, secretion or tissue of a subject, are also provided.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJD39XfxdPN0dVFw8XMMdlVw9HNRCA12DVYI8XANcvV342FgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8aHBRgaGFoaGRkDK0dCYOFUAOLMiKg</recordid><startdate>20180426</startdate><enddate>20180426</enddate><creator>SHAALTIEL, Yoseph</creator><creator>RUDERFER, Ilya</creator><creator>UGORTSEV, Yulia</creator><creator>NETA, Hagit</creator><creator>GELLEY, Sivan</creator><creator>CHEN ZELTSBURG, Lilach</creator><creator>FUX, Liat</creator><creator>LAVEE LAVIAD, Elad</creator><creator>SHULMAN, Avidor</creator><scope>EVB</scope></search><sort><creationdate>20180426</creationdate><title>MODIFIED DNASE AND USES THEREOF</title><author>SHAALTIEL, Yoseph ; RUDERFER, Ilya ; UGORTSEV, Yulia ; NETA, Hagit ; GELLEY, Sivan ; CHEN ZELTSBURG, Lilach ; FUX, Liat ; LAVEE LAVIAD, Elad ; SHULMAN, Avidor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2018112201A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2018</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SHAALTIEL, Yoseph</creatorcontrib><creatorcontrib>RUDERFER, Ilya</creatorcontrib><creatorcontrib>UGORTSEV, Yulia</creatorcontrib><creatorcontrib>NETA, Hagit</creatorcontrib><creatorcontrib>GELLEY, Sivan</creatorcontrib><creatorcontrib>CHEN ZELTSBURG, Lilach</creatorcontrib><creatorcontrib>FUX, Liat</creatorcontrib><creatorcontrib>LAVEE LAVIAD, Elad</creatorcontrib><creatorcontrib>SHULMAN, Avidor</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SHAALTIEL, Yoseph</au><au>RUDERFER, Ilya</au><au>UGORTSEV, Yulia</au><au>NETA, Hagit</au><au>GELLEY, Sivan</au><au>CHEN ZELTSBURG, Lilach</au><au>FUX, Liat</au><au>LAVEE LAVIAD, Elad</au><au>SHULMAN, Avidor</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MODIFIED DNASE AND USES THEREOF</title><date>2018-04-26</date><risdate>2018</risdate><abstract>Modified DNase I protein in which one or more amino acids of a DNase I protein are modified non-cellularly, are provided. The modified DNase I protein exhibits a DNA hydrolytic activity in the presence of actin and an improved DNA hydrolytic activity compared to a homologous non-modified DNase I protein. Processes of preparing the modified DNase I protein and uses thereof in, for example, reducing a DNA content in sputum and/or in treating a disease or condition associated with excess extracellular DNA in a fluid, secretion or tissue of a subject, are also provided.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US2018112201A1 |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | MODIFIED DNASE AND USES THEREOF |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T14%3A18%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=SHAALTIEL,%20Yoseph&rft.date=2018-04-26&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2018112201A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |