SUBSTITUTED AZETIDINYL COMPOUNDS AS GLYT1 INHIBITORS

SUBSTITUTED AZETIDINYL COMPOUNDS AS GLYT1 INHIBITORS

The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, R4, X, and Y have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; de...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Santora Vincent, Basinger Jillian, Hudson Andrew, Bookser Brett, Chen Mi, Renick Joel, Na James
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator Santora Vincent
Basinger Jillian
Hudson Andrew
Bookser Brett
Chen Mi
Renick Joel
Na James
description The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, R4, X, and Y have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by GlyTl activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training; and treating other disorders, including pain and alcohol-dependence.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2017334846A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2017334846A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2017334846A13</originalsourceid><addsrcrecordid>eNrjZDAJDnUKDvEMCQ1xdVFwjHIN8XTx9Iv0UXD29w3wD_VzCVZwDFZw94kMMVTw9PPwdPIM8Q8K5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8aHBRgaG5sbGJhYmZo6GxsSpAgCgSSjQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>SUBSTITUTED AZETIDINYL COMPOUNDS AS GLYT1 INHIBITORS</title><source>esp@cenet</source><creator>Santora Vincent ; Basinger Jillian ; Hudson Andrew ; Bookser Brett ; Chen Mi ; Renick Joel ; Na James</creator><creatorcontrib>Santora Vincent ; Basinger Jillian ; Hudson Andrew ; Bookser Brett ; Chen Mi ; Renick Joel ; Na James</creatorcontrib><description>The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, R4, X, and Y have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by GlyTl activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training; and treating other disorders, including pain and alcohol-dependence.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20171123&amp;DB=EPODOC&amp;CC=US&amp;NR=2017334846A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20171123&amp;DB=EPODOC&amp;CC=US&amp;NR=2017334846A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Santora Vincent</creatorcontrib><creatorcontrib>Basinger Jillian</creatorcontrib><creatorcontrib>Hudson Andrew</creatorcontrib><creatorcontrib>Bookser Brett</creatorcontrib><creatorcontrib>Chen Mi</creatorcontrib><creatorcontrib>Renick Joel</creatorcontrib><creatorcontrib>Na James</creatorcontrib><title>SUBSTITUTED AZETIDINYL COMPOUNDS AS GLYT1 INHIBITORS</title><description>The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, R4, X, and Y have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by GlyTl activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training; and treating other disorders, including pain and alcohol-dependence.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAJDnUKDvEMCQ1xdVFwjHIN8XTx9Iv0UXD29w3wD_VzCVZwDFZw94kMMVTw9PPwdPIM8Q8K5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8aHBRgaG5sbGJhYmZo6GxsSpAgCgSSjQ</recordid><startdate>20171123</startdate><enddate>20171123</enddate><creator>Santora Vincent</creator><creator>Basinger Jillian</creator><creator>Hudson Andrew</creator><creator>Bookser Brett</creator><creator>Chen Mi</creator><creator>Renick Joel</creator><creator>Na James</creator><scope>EVB</scope></search><sort><creationdate>20171123</creationdate><title>SUBSTITUTED AZETIDINYL COMPOUNDS AS GLYT1 INHIBITORS</title><author>Santora Vincent ; Basinger Jillian ; Hudson Andrew ; Bookser Brett ; Chen Mi ; Renick Joel ; Na James</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2017334846A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>Santora Vincent</creatorcontrib><creatorcontrib>Basinger Jillian</creatorcontrib><creatorcontrib>Hudson Andrew</creatorcontrib><creatorcontrib>Bookser Brett</creatorcontrib><creatorcontrib>Chen Mi</creatorcontrib><creatorcontrib>Renick Joel</creatorcontrib><creatorcontrib>Na James</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Santora Vincent</au><au>Basinger Jillian</au><au>Hudson Andrew</au><au>Bookser Brett</au><au>Chen Mi</au><au>Renick Joel</au><au>Na James</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED AZETIDINYL COMPOUNDS AS GLYT1 INHIBITORS</title><date>2017-11-23</date><risdate>2017</risdate><abstract>The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, R4, X, and Y have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by GlyTl activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training; and treating other disorders, including pain and alcohol-dependence.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_epo_espacenet_US2017334846A1
source esp@cenet
subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title SUBSTITUTED AZETIDINYL COMPOUNDS AS GLYT1 INHIBITORS
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T18%3A28%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Santora%20Vincent&rft.date=2017-11-23&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2017334846A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true