AZABENZIMIDAZOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY
Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or a pharmaceutically acceptable salt thereof, wherein R 4 is hydrogen, or substituted or unsubstituted alkyl, R 1 , R 2 and R 3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy,...
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| creator | Fujioka Masahiko Ino Akira Tanaka Nobuyuki Katou Manabu Iwatsu Masafumi Ohyabu Naoki Hinata Yu KOJIMA Eiichi Tonogaki Keisuke |
| description | Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula:
or a pharmaceutically acceptable salt thereof,
wherein R 4 is hydrogen, or substituted or unsubstituted alkyl,
R 1 , R 2 and R 3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R 1 , R 2 and R 3 are not simultaneously hydrogen,
X is a single bond, -S-, -O-, -NR 5 -, -C(=O)- or the like,
R 5 is hydrogen, or substituted or unsubstituted alkyl,
Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like. |
| format | Patent |
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or a pharmaceutically acceptable salt thereof,
wherein R 4 is hydrogen, or substituted or unsubstituted alkyl,
R 1 , R 2 and R 3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R 1 , R 2 and R 3 are not simultaneously hydrogen,
X is a single bond, -S-, -O-, -NR 5 -, -C(=O)- or the like,
R 5 is hydrogen, or substituted or unsubstituted alkyl,
Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like.</description><language>eng</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170420&DB=EPODOC&CC=US&NR=2017107219A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170420&DB=EPODOC&CC=US&NR=2017107219A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Fujioka Masahiko</creatorcontrib><creatorcontrib>Ino Akira</creatorcontrib><creatorcontrib>Tanaka Nobuyuki</creatorcontrib><creatorcontrib>Katou Manabu</creatorcontrib><creatorcontrib>Iwatsu Masafumi</creatorcontrib><creatorcontrib>Ohyabu Naoki</creatorcontrib><creatorcontrib>Hinata Yu</creatorcontrib><creatorcontrib>KOJIMA Eiichi</creatorcontrib><creatorcontrib>Tonogaki Keisuke</creatorcontrib><title>AZABENZIMIDAZOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY</title><description>Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula:
or a pharmaceutically acceptable salt thereof,
wherein R 4 is hydrogen, or substituted or unsubstituted alkyl,
R 1 , R 2 and R 3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R 1 , R 2 and R 3 are not simultaneously hydrogen,
X is a single bond, -S-, -O-, -NR 5 -, -C(=O)- or the like,
R 5 is hydrogen, or substituted or unsubstituted alkyl,
Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLB2jHJ0cvWL8vT1dHGM8vdxVXBxDfIMcwzxDHNV8HAM8_RzV3D0DfDWdXQOAQuD-CCmZ0gkDwNrWmJOcSovlOZmUHZzDXH20E0tyI9PLS5ITE7NSy2JDw02MjA0NzQwNzK0dDQ0Jk4VALCEKpg</recordid><startdate>20170420</startdate><enddate>20170420</enddate><creator>Fujioka Masahiko</creator><creator>Ino Akira</creator><creator>Tanaka Nobuyuki</creator><creator>Katou Manabu</creator><creator>Iwatsu Masafumi</creator><creator>Ohyabu Naoki</creator><creator>Hinata Yu</creator><creator>KOJIMA Eiichi</creator><creator>Tonogaki Keisuke</creator><scope>EVB</scope></search><sort><creationdate>20170420</creationdate><title>AZABENZIMIDAZOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY</title><author>Fujioka Masahiko ; Ino Akira ; Tanaka Nobuyuki ; Katou Manabu ; Iwatsu Masafumi ; Ohyabu Naoki ; Hinata Yu ; KOJIMA Eiichi ; Tonogaki Keisuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2017107219A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2017</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Fujioka Masahiko</creatorcontrib><creatorcontrib>Ino Akira</creatorcontrib><creatorcontrib>Tanaka Nobuyuki</creatorcontrib><creatorcontrib>Katou Manabu</creatorcontrib><creatorcontrib>Iwatsu Masafumi</creatorcontrib><creatorcontrib>Ohyabu Naoki</creatorcontrib><creatorcontrib>Hinata Yu</creatorcontrib><creatorcontrib>KOJIMA Eiichi</creatorcontrib><creatorcontrib>Tonogaki Keisuke</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Fujioka Masahiko</au><au>Ino Akira</au><au>Tanaka Nobuyuki</au><au>Katou Manabu</au><au>Iwatsu Masafumi</au><au>Ohyabu Naoki</au><au>Hinata Yu</au><au>KOJIMA Eiichi</au><au>Tonogaki Keisuke</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>AZABENZIMIDAZOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY</title><date>2017-04-20</date><risdate>2017</risdate><abstract>Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula:
or a pharmaceutically acceptable salt thereof,
wherein R 4 is hydrogen, or substituted or unsubstituted alkyl,
R 1 , R 2 and R 3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R 1 , R 2 and R 3 are not simultaneously hydrogen,
X is a single bond, -S-, -O-, -NR 5 -, -C(=O)- or the like,
R 5 is hydrogen, or substituted or unsubstituted alkyl,
Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | AZABENZIMIDAZOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY |
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