COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF

COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF

The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl) pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its...

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Hauptverfasser: ISBESTER Paul K, SALSBURY Jonathon, HANGAUER, JR. David G, CODY Jeremy A, PATRA Debasis, PALMER Grant J
Format: Patent
Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator ISBESTER Paul K
SALSBURY Jonathon
HANGAUER, JR. David G
CODY Jeremy A
PATRA Debasis
PALMER Grant J
description The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl) pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF
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