Antigen Binding Constructs

Antigen Binding Constructs

The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention,...

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Hauptverfasser: Hughes-Thomas Zoe, Lewis Alan Peter, Steward Michael, ASHMAN Claire, Catchpole Ian Richard
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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creator Hughes-Thomas Zoe
Lewis Alan Peter
Steward Michael
ASHMAN Claire
Catchpole Ian Richard
description The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD), diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs.
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Lewis Alan Peter ; Steward Michael ; ASHMAN Claire ; Catchpole Ian Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2017029494A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><toplevel>online_resources</toplevel><creatorcontrib>Hughes-Thomas Zoe</creatorcontrib><creatorcontrib>Lewis Alan Peter</creatorcontrib><creatorcontrib>Steward Michael</creatorcontrib><creatorcontrib>ASHMAN Claire</creatorcontrib><creatorcontrib>Catchpole Ian Richard</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Hughes-Thomas Zoe</au><au>Lewis Alan Peter</au><au>Steward Michael</au><au>ASHMAN Claire</au><au>Catchpole Ian Richard</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Antigen Binding Constructs</title><date>2017-02-02</date><risdate>2017</risdate><abstract>The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD), diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs.</abstract><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title Antigen Binding Constructs
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