PROLINE-RICH PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE

The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and...

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Hauptverfasser:	Ghasparian Arin, Pluschke Gerd, Geib Nina, Tamborini Marco, Jud Maja, Robinson John Anthony, Marrero Nodarse Aniebrys, Zuniga Armando
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator	Ghasparian Arin Pluschke Gerd Geib Nina Tamborini Marco Jud Maja Robinson John Anthony Marrero Nodarse Aniebrys Zuniga Armando
description	The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and positively charged amino acid, and at least 15% of the amino acids are proline. Such synthetic virus-like particles carrying proline-rich antigens derived from pneumococcal proteins are useful as vaccines against infectious diseases caused by Gram-positive bacteria such as Streptococcus pneumoniae.
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subjects	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title	PROLINE-RICH PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE
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