METHOD FOR PREPARING HEPATOCYTE AND METHOD FOR EVALUATING DRUG HEPATOTOXICITY OF INTEREST

METHOD FOR PREPARING HEPATOCYTE AND METHOD FOR EVALUATING DRUG HEPATOTOXICITY OF INTEREST

A method for preparing a hepatocyte includes the following steps: providing a liver progenitor cell, proliferating the liver progenitor cell in a medium supplemented with nicotinamide, insulin-transferrin-selenium (ITS) and EGF, and inducing the liver progenitor cell into the hepatocyte having a hep...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Chen Chen-Ming, Hsu Lih-Tao, Chen Wannhsin
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PHYSICS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
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Beschreibung
Zusammenfassung:A method for preparing a hepatocyte includes the following steps: providing a liver progenitor cell, proliferating the liver progenitor cell in a medium supplemented with nicotinamide, insulin-transferrin-selenium (ITS) and EGF, and inducing the liver progenitor cell into the hepatocyte having a hepatic cord-like structure morphology. In one embodiment, the method further includes providing a pluripotent stem cell and differentiating the pluripotent stem cell into the liver progenitor cell.