VACCINE COMPRISING PROTEIN NMB0964 FROM NEISSERIA MENINGITIDIS

VACCINE COMPRISING PROTEIN NMB0964 FROM NEISSERIA MENINGITIDIS

The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bactericidal antibodies are generated against said antigen. It has been found for the first time that this antigen's expression is zinc regulated and t...

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Hauptverfasser: Stork Michiel, Weynants Vincent, Bos Martine Petronella, Tommassen Johannes Petrus Maria, Poolman Jan
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator Stork Michiel
Weynants Vincent
Bos Martine Petronella
Tommassen Johannes Petrus Maria
Poolman Jan
description The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bactericidal antibodies are generated against said antigen. It has been found for the first time that this antigen's expression is zinc regulated and therefore methods are provided to upregulated expression through removal of the zinc repression mechanism of the cell or promoter, or through removal of zinc from the culture medium.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title VACCINE COMPRISING PROTEIN NMB0964 FROM NEISSERIA MENINGITIDIS
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