Compositions and Methods for Treating Cancer with JAK2 Activity

Methods and compositions for diagnosing and treating JAK2 inhibitor resistant cancers are disclosed. In the disclosed methods, AKT and/or PI3K inhibitors, ERK/MEK inhibitors, BCL-XL protein inhibitors, or combinations thereof are administered to a subject to reverse JAK2 inhibitor resistance. Accord...

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Hauptverfasser:	Wood Kris Cameron, Winter Peter Saville
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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creator	Wood Kris Cameron Winter Peter Saville
description	Methods and compositions for diagnosing and treating JAK2 inhibitor resistant cancers are disclosed. In the disclosed methods, AKT and/or PI3K inhibitors, ERK/MEK inhibitors, BCL-XL protein inhibitors, or combinations thereof are administered to a subject to reverse JAK2 inhibitor resistance. Accordingly, compositions containing such inhibitors may be used along with JAK2 inhibitors to successfully treat JAK2 inhibitor resistant cancers.
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In the disclosed methods, AKT and/or PI3K inhibitors, ERK/MEK inhibitors, BCL-XL protein inhibitors, or combinations thereof are administered to a subject to reverse JAK2 inhibitor resistance. 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title	Compositions and Methods for Treating Cancer with JAK2 Activity
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