PREPARATION AND USE OF 7A-AMIDE SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS

The present invention relates to bicyclic himbacine derivatives of the formula or a pharmaceutically acceptable salt thereof wherein: R1 is -[C(Ra)(Rb)]x-[C(Rb)(Rb)]y-C(O)NH2, or -N(H)-[(CH2)]z-C(O)-NH2, W is and the remaining variables are described herein. The compounds of the invention are effect...

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Bibliographische Detailangaben

Hauptverfasser:	ZHANG FENGQI, KNOWLES SANDRA LEE, YANG ZHIQIANG, DONG GUIZHEN, MALETIC MILANA
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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